[关闭]
您好！欢迎来到炼石商城   请登录  注册    兼职小伙伴  
我的购物车
0
Qiagen 凯杰 Biosharp Omega

首页抗体Millipore 密理博>

图片仅供参考，请以实物为准
收藏

Ms X p21

市场价：
0.00
促销价：
¥0.00

货号：MAB88058

品牌：Millipore 密理博

配送至：

支付： 账期 货到付款

数量：

EA (预计3-5工作日到货)

亲，想了解价格请QQ咨询客服！

工作时间

周一至周五：9:00-18:00

咨询电话

0771-3293894

在线咨询

客服 郭恒 蔡玉坤 曾宪飞 技术咨询

浏览了该商品的用户最终购买

RNeasy Mini Kit (50) 50次
RNeasy Mini Kit (50) 50次
3720.00
Plasmid Mini Kit I(200) 200次
Plasmid Mini Kit I(200) 200...
576.00
10ul吸头，透明，袋装，可灭菌 1000支/袋，50袋/箱
10ul吸头，透明，袋装，可灭菌...
85.80

浏览了该商品的用户还浏览了

QIAfilter Plasmid Maxi Kit (10) -10
QIAfilter Plasmid Maxi Kit (...
3000.00
QIAamp DNA Blood Midi Kit (20) 20次
QIAamp DNA Blood Midi Kit (2...
2680.00
QIAamp UCP Pathogen Mini Kit (50)
QIAamp UCP Pathogen Mini Kit...
4112.00
Replacement Information

特卖

100% Performance Guaranteed

重要规格表

Species Reactivity Key Applications Host Format Antibody Type
B, H, R FC, IP, IH(P) M Purified Monoclonal Antibody
Description
Catalogue Number MAB88058
Brand Family Chemicon®
Trade Name
  • Chemicon
Description Anti-p21waf1 Antibody, clone HZ52
Alternate Names
  • Cip1
  • MDA-6
References
Product Information
Format Purified
Control
  • POSITIVE CONTROL: Ls174T, Raji, Hs27, U20S, MCF-7 cells. Rat/Mouse embryonic fibroblast cells treated with DNA damaging agents. Skin, colon, or breast carcinoma.
Presentation Purified immunoglobulin. Liquid containing 10 mM PBS, pH 7.4, with 0.2% BSA and 0.09% sodium azide.
Applications
Application Use Anti-p21waf1 Antibody, clone HZ52 (Mouse Monoclonal Antibody) validated in FC, IP, IHC(P) to detect p21waf1 also known as Cip1, MDA-6.
Key Applications
  • Flow Cytometry
  • Immunoprecipitation
  • Immunohistochemistry (Paraffin)
Application Notes Immunohistochemistry: 2-5 μg/mL on formalin-fixed paraffin-embedded tissue sections. High temperature antigen retrieval in 10mM citrate buffer, pH 6.0, is strongly recommended.

Flow Cytometry

Immunoprecipitation: 2 μg (antibody)/mg protein lysate. The use of protein G to precipitate antigen-antibody complexes is recommended.



Optimal working dilutions must be determined by end user.
Biological Information
Immunogen Full length human recombinant p21 protein.
Clone HZ52
Concentration Please refer to the Certificate of Analysis for the lot-specific concentration.
Host Mouse
Specificity Monoclonal antibody MAB88058 recognizes an 18 to 21 kDa protein, identified as the p21WAF1/cip1/sdi1/pic1 tumor suppressor protein. MAB88058 is highly specific to p21 and shows no cross-reaction with other closely related mitotic inhibitors. p21WAF1 is a specific inhibitor of cdk's and a tumor suppressor involved in the pathogenesis of a variety of malignancies. Expression of p21WAF1 is induced by wild type, but not mutant, p53 suppressor protein.

CELLULAR LOCALIZATION:

Predominant nuclear
Isotype IgG1
Species Reactivity
  • Bovine
  • Human
  • Rat
Antibody Type Monoclonal Antibody
Entrez Gene Number
Entrez Gene Summary This gene encodes a potent cyclin-dependent kinase inhibitor. The encoded protein binds to and inhibits the activity of cyclin-CDK2 or -CDK4 complexes, and thus functions as a regulator of cell cycle progression at G1. The expression of this gene is tightly controlled by the tumor suppressor protein p53, through which this protein mediates the p53-dependent cell cycle G1 phase arrest in response to a variety of stress stimuli. This protein can interact with proliferating cell nuclear antigen (PCNA), a DNA polymerase accessory factor, and plays a regulatory role in S phase DNA replication and DNA damage repair. This protein was reported to be specifically cleaved by CASP3-like caspases, which thus leads to a dramatic activation of CDK2, and may be instrumental in the execution of apoptosis following caspase activation. Two alternatively spliced variants, which encode an identical protein, have been reported.
Gene Symbol
  • CDKN1A
  • P21
  • MDA-6
  • SDI1
  • MDA6
  • p21
  • p21CIP1
  • PIC1
  • CIP1
  • CDKN1
  • WAF1
  • CAP20
UniProt Number
UniProt Summary FUNCTION: SwissProt: P38936 # May be the important intermediate by which p53 mediates its role as an inhibitor of cellular proliferation in response to DNA damage. Binds to and inhibits cyclin-dependent kinase activity, preventing phosphorylation of critical cyclin-dependent kinase substrates and blocking cell cycle progression.
SIZE: 164 amino acids; 18119 Da
SUBCELLULAR LOCATION: Cytoplasm. Nucleus.
TISSUE SPECIFICITY: Expressed in all adult human tissues, with 5- fold lower levels observed in the brain.
PTM: Phosphorylation of Thr-145 by Akt or of Ser-146 by PKC impairs binding to PCNA.
SIMILARITY: SwissProt: P38936 ## Belongs to the CDI family.
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage Conditions Maintain at 2-8°C in undiluted aliquots for up to 12 months.
Packaging Information
Material Size 50 µg
Transport Information
Supplemental Information
Specifications

温馨提示:因厂家更改产品包装、产地或者更换随机附件等没有任何提前通知，且每位咨询者购买情况、提问时间等不同，为此以下回复仅对提问者3天内有效，其他网友仅供参考！若由此给您带来不便请多多谅解，谢谢！

我要咨询

咨询内容：
购物指南 免费注册 批量采购 购物流程 购物保障
配送方式 上门自提 第三方配送 炼石配送
支付方式 货到付款 账期付款
售后服务 售后政策 退款说明 售后流程 免责条款

服务热线

0771-3293894

关于我们|帮助中心|诚聘英才|炼石云实验室|联系我们|友情链接

Copyright 2014-2025 炼石云商网络科技（海南）有限公司版权所有 琼ICP备2023006525号-3