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Ms X Renin

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货号：MAB10212

品牌：Millipore 密理博

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重要规格表

Species Reactivity Key Applications Host Format Antibody Type
Po WB M Ascites Monoclonal Antibody
Description
Catalogue Number MAB10212
Brand Family Chemicon®
Trade Name
  • Chemicon
Description Anti-Renin Antibody, clone F32 VIII C4
Background Information Renin is processed as a 406 amino acid precursor (45 kDa) containing a 23 amino acid signal peptide and a 43 amino acid propeptide that is released from renal juxtaglomerular cells in response to sodium depletion, decreased blood volume and blood pressure, and b-adrenergic stimulation. Renin initiates a sequence of steps that begins with cleavage of a decapeptide angiotensin I from renin substrate (angiotensinogen), an alpha-2-globulin produced in the liver (and other organs including the kidney.
References
Product Information
Format Ascites
Presentation Liquid ascites fluid
Applications
Application Anti-Renin Antibody, clone F32 VIII C4 detects level of Renin & has been published & validated for use in WB.
Key Applications
  • Western Blotting
Biological Information
Immunogen Purified hog renin
Clone F32 VIII C4
Host Mouse
Isotype IgG1
Species Reactivity
  • Pig
Antibody Type Monoclonal Antibody
Entrez Gene Number
Entrez Gene Summary Renin catalyzes the first step in the activation pathway of angiotensinogen--a cascade that can result in aldosterone release,vasoconstriction, and increase in blood pressure. Renin, an aspartyl protease, cleaves angiotensinogen to form angiotensin I, which is converted to angiotensin II by angiotensin I converting enzyme, an important regulator of blood pressure and electrolyte balance. Transcript variants that encode different protein isoforms and that arise from alternative splicing and the use of alternative promoters have been described, but their full-length nature has not been determined. Mutations in this gene have been shown to cause familial hyperproreninemia.
Gene Symbol
  • REN
  • Angiotensinogenase
  • angiotensinogenase
  • renin
  • FLJ10761
  • EC 3.4.23.15
Purification Method Ascites
UniProt Number
UniProt Summary FUNCTION: SwissProt: P00797 # Renin is a highly specific endopeptidase, whose only known function is to generate angiotensin I from angiotensinogen in the plasma, initiating a cascade of reactions that produce an elevation of blood pressure and increased sodium retention by the kidney.
SIZE: 406 amino acids; 45057 Da
SUBUNIT: Interacts with ATP6AP2.
SUBCELLULAR LOCATION: Secreted. Membrane. Note=Associated to membranes via binding to ATP6AP2.
DISEASE: SwissProt: P00797 # Defects in REN are a cause of renal tubular dysgenesis (RTD) [MIM:267430]. RTD is an autosomal recessive severe disorder of renal tubular development characterized by persistent fetal anuria and perinatal death, probably due to pulmonary hypoplasia from early-onset oligohydramnios (the Potter phenotype).
SIMILARITY: SwissProt: P00797 ## Belongs to the peptidase A1 family.
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage Conditions 1 year at 2-8°C from date of receipt
Packaging Information
Material Size 100 µL
Transport Information
Supplemental Information
Specifications

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