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Ms X cdk4

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货号：MAB8879

品牌：Millipore 密理博

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Replacement Information

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重要规格表

Species Reactivity Key Applications Host Format Antibody Type
H, M, Po, R IF, IP, Enzyme Assays, WB, IHC M Purified Monoclonal Antibody
Description
Catalogue Number MAB8879
Replaces MABE548
Brand Family Chemicon®
Trade Name
  • Chemicon
Description Anti-Cdk4 Antibody, clone DCS-35
Background Information The prototype of the cdk family, p34cdc2, and a related protein cdk2, function late in the cycle while cdk4 and cdk6 are critically involved in G1 to S progression.
References
Product Information
Format Purified
Presentation Purified immunoglobulin. Liquid containing 10 mM PBS, pH 7.4 with 0.2% BSA and 0.09% sodium azide.
Applications
Application Detect Cdk4 with Anti-Cdk4 Antibody, clone DCS-35 (Mouse Monoclonal Antibody), that has been shown to work in IF, IP, EA, WB & IHC.
Key Applications
  • Immunofluorescence
  • Immunoprecipitation
  • Enzyme Assays
  • Western Blotting
  • Immunohistochemistry
Application Notes Immunofluorescence

Immunoprecipitation: excellent for coprecipitation of D-type cyclins bound to cdk4.

Western Blotting: 2-4 ug/mL

Kinase Assay

The prototype of the cdk family, p34cdc2, and a related protein cdk2, function late in the cycle while cdk4 and cdk6 are critically involved in G1 to S progression.

Optimal working dilutions must be determined by the end user.
Biological Information
Immunogen Raised against purified recombinant cdk4 protein.
Clone DCS-35
Concentration Please refer to the Certificate of Analysis for the lot-specific concentration.
Host Mouse
Specificity Recognizes a 34 kDa protein identified as p34 or cyclin-dependent kinase 4 (cdk4). It shows no cross-reaction with other cdks.
Isotype IgG1κ
Species Reactivity
  • Human
  • Mouse
  • Pig
  • Rat
Antibody Type Monoclonal Antibody
Entrez Gene Number
Entrez Gene Summary The protein encoded by this gene is a member of the Ser/Thr protein kinase family. This protein is highly similar to the gene products of S. cerevisiae cdc28 and S. pombe cdc2. It is a catalytic subunit of the protein kinase complex that is important for cell cycle G1 phase progression. The activity of this kinase is restricted to the G1-S phase, which is controlled by the regulatory subunits D-type cyclins and CDK inhibitor p16(INK4a). This kinase was shown to be responsible for the phosphorylation of retinoblastoma gene product (Rb). Mutations in this gene as well as in its related proteins including D-type cyclins, p16(INK4a) and Rb were all found to be associated with tumorigenesis of a variety of cancers. Multiple polyadenylation sites of this gene have been reported.
Gene Symbol
  • CDK4
  • PSK-J3
  • CMM3
  • MGC14458
  • EC 2.7.11.22
UniProt Number
UniProt Summary FUNCTION: SwissProt: P11802 # Probably involved in the control of the cell cycle.
SIZE: 303 amino acids; 33730 Da
SUBUNIT: Forms a stable complex with D-type G1 cyclins. Interacts with SEI1 and ZNF655/VIK.
DISEASE: SwissProt: P11802 # CDK4 mutations are involved in tumor formation. & Defects in CDK4 are the cause of cutaneous malignant melanoma 3 (CMM3) [MIM:609048, 155600]. Malignant melanoma is a malignant neoplasm of melanocytes, arising de novo or from a preexisting benign nevus, which occurs most often in the skin but also may involve other sites.
SIMILARITY: SwissProt: P11802 ## Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily. & Contains 1 protein kinase domain.
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage Conditions Maintain liquid material at 2-8°C for up to 24 months.
Packaging Information
Material Size 50 µg
Transport Information
Supplemental Information
Specifications

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