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Anti-Human Serum Amyloid P.(mouse monoclonal)

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货号：CBL305

品牌：Millipore 密理博

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重要规格表

Species Reactivity Key Applications Host Format Antibody Type
H ELISA M Purified Monoclonal Antibody
Description
Catalogue Number CBL305
Brand Family Chemicon®
Trade Name
  • Chemicon
Description Anti-Serum Amyloid P Antibody, clone 5.4D.3B
Alternate Names
  • Component P
Background Information Amyloid consists mainly of rigid, non-branching protein fibrils, together with rod-like aggregates of a pentagonal-shaped glycoprotein called amyloid P protein. Amyloid P protein, also known as component P, comprises 10 per cent of amyloid tissue and is present in all but the central nervous system forms of amyloid. Amyloid P protein is a constituent of normal basement membranes and the microfibrillaryelastic fiber network.
References
Product Information
Format Purified
Presentation The monoclonal is presented at a concentration of 100ug in phosphate buffered saline containing 10mM sodium azide. We recommend that each laboratory determine an optimum working titre for use in its particular application.
Applications
Application Anti-Serum Amyloid P Antibody, clone 5.4D.3B is an antibody against Serum Amyloid P for use in ELISA.
Key Applications
  • ELISA
Application Notes Development of ELISA assay for the estimation of human serum amyloid P using conjugated CBL304.

Optimal working dilutions must be determined by the end user.
Biological Information
Immunogen Human serum amyloid P
Clone 5.4D.3B
Host Mouse
Specificity This antibody is specific for human serum amyloid P.

FUSION PARTNER: NS1 myeloma cell line
Isotype IgG1
Species Reactivity
  • Human
Antibody Type Monoclonal Antibody
Entrez Gene Number
Entrez Gene Summary The protein encoded by this gene is a glycoprotein, belonging to the pentraxin family of proteins, which has a characteristic pentameric organization. These family members have considerable sequence homology which is thought to be the result of gene duplication. The binding of the encoded protein to proteins in the pathological amyloid cross-beta fold suggests its possible role as a chaperone. This protein is also thought to control the degradation of chromatin. It has been demonstrated that this protein binds to apoptotic cells at an early stage, which raises the possibility that it is involved in dealing with apoptotic cells in vivo.
Gene Symbol
  • SAP
  • SAMP
  • APCS
  • PTX2
UniProt Number
UniProt Summary FUNCTION: Can interact with DNA and histones and may scavenge nuclear material released from damaged circulating cells. May also function as a calcium-dependent lectin.
COFACTOR: Binds 2 calcium ions per subunit.
SUBUNIT: Homopentamer. Pentaxin (or pentraxin) have a discoid arrangement of 5 non-covalently bound subunits.
SUBCELLULAR LOCATION: Secreted.
TISSUE SPECIFICITY: Found in serum and urine.
PTM: N-glycosylated with a complex biantennary oligosaccharide chain with a sialic acid at the end (disialo-SAP). Monosialo-SAP as well as asioalo-SAP are also detected.
DISEASE: SAP is a precursor of amyloid component P which is found in basement membrane and associated with amyloid deposits.
SIMILARITY: Belongs to the pentaxin family.
SIMILARITY: Contains 1 pentaxin domain.
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage Conditions For use within 1 month of purchase store at +4°C, for long term storage aliquot antibody into small volumes and store at -20°C.
Packaging Information
Material Size 100 µg
Transport Information
Supplemental Information
Specifications

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