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Rb X NARC-1

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货号：AB15115

品牌：Millipore 密理博

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重要规格表

Species Reactivity Key Applications Host Format Antibody Type
M WB Rb Serum Polyclonal Antibody
Description
Catalogue Number AB15115
Brand Family Chemicon®
Trade Name
  • Chemicon
Description Anti-NARC-1 Antibody
Alternate Names
  • Neural Apoptosis-Regulated Convertase 1
  • PCSK9
References
Product Information
Format Serum
Presentation Rabbit serum.
Applications
Application NARC-1 is an antibody targeting the NARC-1 protein, validated for use in WB.
Key Applications
  • Western Blotting
Biological Information
Immunogen Synthetic peptide.
Host Rabbit
Specificity Neural apoptosis-regulated convertase 1 [NARC-1, Pcsk9]. By Western blot the antibody recognizes a doublet at ~76 kDa in mouse liver lysate.
Species Reactivity
  • Mouse
Antibody Type Polyclonal Antibody
Entrez Gene Number
Entrez Gene Summary This gene encodes a proprotein convertase belonging to the proteinase K subfamily of the secretory subtilase family. The encoded protein is synthesized as a soluble zymogen that undergoes autocatalytic intramolecular processing in the endoplasmic reticulum. The protein may function as a proprotein convertase. This protein plays a role in cholesterol homeostasis and may have a role in the differentiation of cortical neurons. Mutations in this gene have been associated with a third form of autosomal dominant familial hypercholesterolemia (HCHOLA3).
Gene Symbol
  • PCSK9
  • NARC1
  • NARC-1
  • FH3
  • HCHOLA3
Purification Method Serum
UniProt Number
UniProt Summary FUNCTION: SwissProt: Q8NBP7 # May be implicated in the differentiation of cortical neurons and may play a role in cholesterol homeostasis.
COFACTOR: Calcium (Probable).
SIZE: 692 amino acids; 74372 Da
SUBUNIT: The precursor protein but not the mature protein may form multimers.
SUBCELLULAR LOCATION: Secreted.
TISSUE SPECIFICITY: Expressed in neuro-epithelioma, colon carcinoma, hepatic and pancreatic cell lines, and in Schwann cells.
PTM: The soluble zymogen undergoes autocatalytic intramolecular processing in the endoplasmic reticulum, resulting in the cleavage of its propeptide that remains associated with the secreted enzyme.
DISEASE:SwissProt: Q8NBP7 # Defects in PCSK9 are the cause of familial hypercholesterolemia 3 (FH3) [MIM:603776]. FH3 inheritance is autosomal dominant.
SIMILARITY: SwissProt: Q8NBP7 ## Belongs to the peptidase S8 family. & Contains 1 peptidase S8 domain.
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage Conditions Maintain at -20degC in undiluted aliquots for up to 12 months after date of receipt. Avoid repeated freeze/thaw cycles.
Packaging Information
Material Size 100 µL
Transport Information
Supplemental Information
Specifications

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