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Ms X Human Plasma Fibronectin

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货号：MAB1932

品牌：Millipore 密理博

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重要规格表

Species Reactivity Key Applications Host Format Antibody Type
Ca, H ELISA, WB M Purified Monoclonal Antibody
Description
Catalogue Number MAB1932
Brand Family Chemicon®
Trade Name
  • Chemicon
Description Anti-Fibronectin Antibody, mid-molecule, clone 875A51
References
Product Information
Format Purified
Presentation Liquid in 0.02M PB with 0.25M NaCl,pH=7.6, 0.1% sodium azide.
Applications
Application Detect Fibronectin using this Anti-Fibronectin Antibody, mid-molecule, clone 875A51 validated for use in ELISA & WB.
Key Applications
  • ELISA
  • Western Blotting
Application Notes ELISA

Microscopy

Western blotting at 1-5 μg/ml

Final working dilutions must be determined by end user.
Biological Information
Immunogen Human plasma fibronectin.
Epitope mid-molecule
Clone 875A51
Host Mouse
Specificity Reacts with the middle (central domain) of the human plasma fibronectin monomer but does not interfere with cell adhesion. Positive reactivity with human and canine samples. Negative reactivity with chick.
Isotype IgG1
Species Reactivity
  • Canine
  • Human
Antibody Type Monoclonal Antibody
Entrez Gene Number
Entrez Gene Summary This gene encodes fibronectin, a glycoprotein present in a soluble dimeric form in plasma, and in a dimeric or multimeric form at the cell surface and in extracellular matrix. Fibronectin is involved in cell adhesion and migration processes including embryogenesis, wound healing, blood coagulation, host defense, and metastasis. The gene has three regions subject to alternative splicing, with the potential to produce 20 different transcript variants. However, the full-length nature of some variants has not been determined.
Gene Symbol
  • FN1
  • DKFZp686H0342
  • DKFZp686I1370
  • MSF
  • CIG
  • LETS
  • DKFZp686O13149
  • FN
  • DKFZp686F10164
  • FINC
UniProt Number
UniProt Summary FUNCTION: SwissProt: P02751 # Fibronectins bind cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and actin. Fibronectins are involved in cell adhesion, cell motility, opsonization, wound healing, and maintenance of cell shape. Interaction with TNR mediates inhibition of cell adhesion and neurite outgrowth (By similarity).
SIZE: 2386 amino acids; 262607 Da
SUBUNIT: Mostly heterodimers or multimers of alternatively spliced variants, connected by 2 disulfide bonds near the carboxyl ends; to a lesser extent homodimers. Interacts with FBLN1, AMBP, TNR, LGALS3BP and COL13A1.
SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular matrix.
TISSUE SPECIFICITY: Plasma FN (soluble dimeric form) is secreted by hepatocytes. Cellular FN (dimeric or cross-linked multimeric forms), made by fibroblasts, epithelial and other cell types, is deposited as fibrils in the extracellular matrix. Ugl-Y1, Ugl-Y2 and Ugl-Y3 are found in urine.DEVELOPMENTAL STAGE: Ugl-Y1, Ugl-Y2 and Ugl-Y3 are present in the urine from 0 to 17 years of age.
PTM: Sulfated.
SIMILARITY: SwissProt: P02751 ## Contains 12 fibronectin type-I domains. & Contains 2 fibronectin type-II domains. & Contains 16 fibronectin type-III domains.
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage Conditions Maintain at 2-8°C.
Packaging Information
Material Size 500 µg
Transport Information
Supplemental Information
Specifications

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