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Anti-Integrin alpha2, clone P1E6, azide free

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号:MAB1950Z

牌:Millipore 密理博

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Replacement Information

重要规格表

Species Reactivity Key Applications Host Format Antibody Type
H ICC, IHC, FUNC M Purified Monoclonal Antibody
Description
Catalogue Number MAB1950Z
Brand Family Chemicon®
Trade Name
  • Chemicon
Description Anti-Integrin α2 Antibody, clone P1E6, azide free
Alternate Names
  • CD49b
  • MAB1950
References
Product Information
Format Purified
Control
  • Skin (Basement membrane)
Presentation Protein A Purified mouse immunoglobulin in 0.01 M phosphate buffered saline, pH 7.1, with no preservatives.
Applications
Application This Anti-Integrin α2 Antibody, clone P1E6, azide free is validated for use in IC, IH, FUNC for the detection of Integrin α2.
Key Applications
  • Immunocytochemistry
  • Immunohistochemistry
  • Affects Function
Applications Not Recommended
  • Immunohistochemistry (Paraffin)
Application Notes Suitable for use in attachment inhibition assays using fibroblasts, epithelial cells, endothelial cells, and non-activated platelets on collagen types I, III, IV, VI and laminin.

Suitable for immunofluorescence using fresh frozen or acetone fixed tissues. Not recommended for traditional formalin fixed paraffin embedded tissues.

Final working dilutions must be determined by end user.
Biological Information
Clone P1E6
Concentration Please refer to the Certificate of Analysis for the lot-specific concentration.
Host Mouse
Specificity Recognizes Alpha 2 integrin.
Isotype IgG1
Species Reactivity
  • Human
Antibody Type Monoclonal Antibody
Entrez Gene Number
Entrez Gene Summary This gene product belongs to the integrin alpha chain family. Integrins are heterodimeric integral membrane glycoproteins composed of a distinct alpha chain and a common beta chain. They are found on a wide variety of cell types including, T cells, fibroblasts and platelets. Integrins are involved in cell adhesion and also participate in cell-surface mediated signalling.
Gene Symbol
  • ITGA2
  • CD49B
  • VLAA2
  • VLA-2
  • CD49b
  • BR
  • GPIa
Purification Method Protein A Purfied
UniProt Number
UniProt Summary FUNCTION: SwissProt: P17301 # Integrin alpha-2/beta-1 is a receptor for laminin, collagen, collagen C-propeptides, fibronectin and E-cadherin. It recognizes the proline-hydroxylated sequence G-F-P-G-E-R in collagen. It is responsible for adhesion of platelets and other cells to collagens, modulation of collagen and collagenase gene expression, force generation and organization of newly synthesized extracellular matrix.
SIZE: 1181 amino acids; 129295 Da
SUBUNIT: Heterodimer of an alpha and a beta subunit. Alpha-2 associates with beta-1. Interacts with HPS5.
SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.
DOMAIN: SwissProt: P17301 The integrin I-domain (insert) is a VWFA domain. Integrins with I-domains do not undergo protease cleavage.
SIMILARITY: Belongs to the integrin alpha chain family. & Contains 7 FG-GAP repeats. & Contains 1 VWFA domain.
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage Conditions Maintain for 1 year at 2–8°C from date of shipment. Aliquot to avoid repeated freezing and thawing. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Packaging Information
Material Size 100 µg
Transport Information
Supplemental Information
Specifications

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