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Ms X Hu Integrin alpha V

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货号：MAB1953

品牌：Millipore 密理博

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Replacement Information

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重要规格表

Species Reactivity Key Applications Host Format Antibody Type
H ELISA, FC, IP, ICC, IHC M Purified Monoclonal Antibody
Description
Catalogue Number MAB1953
Brand Family Chemicon®
Trade Name
  • Chemicon
Description Anti-Integrin αV Antibody, clone P3G8
Alternate Names
  • CD51
References
Product Information
Format Purified
Applications
Application Anti-Integrin αV Antibody, clone P3G8 is an antibody against Integrin αV for use in ELISA, FC, IP, IC, IH.
Key Applications
  • ELISA
  • Flow Cytometry
  • Immunoprecipitation
  • Immunocytochemistry
  • Immunohistochemistry
Application Notes Immunohistochemistry: 1:1,000. For use on acetone or paraformaldehyde fixed tissue

Immunocytochemistry: 1:1,000. Will react with some lymphoid cell lines (B cells), many carcinoma and melanoma cell lines and osteosarcomas.

Flow cytometry

Immunoprecipitation

FACS

EIA

Optimal working dilutions must be determined by end user.
Biological Information
Immunogen UCLA P3 lung carcinoma cells
Clone P3G8
Concentration Please refer to the Certificate of Analysis for the lot-specific concentration.
Host Mouse
Specificity Reacts with human alphaV integrin subunit and with all alphaV-containing integrin receptors.
Isotype IgG1
Species Reactivity
  • Human
Antibody Type Monoclonal Antibody
Entrez Gene Number
Entrez Gene Summary ITAGV encodes integrin alpha chain V. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. The I-domain containing integrin alpha V undergoes post-translational cleavage to yield disulfide-linked heavy and light chains, that combine with multiple integrin beta chains to form different integrins. Among the known associating beta chains (beta chains 1,3,5,6, and 8; 'ITGB1', 'ITGB3', 'ITGB5', 'ITGB6', and 'ITGB8'), each can interact with extracellular matrix ligands; the alpha V beta 3 integrin, perhaps the most studied of these, is referred to as the Vitronectin receptor (VNR). In addition to adhesion, many integrins are known to facilitate signal transduction.
Gene Symbol
  • ITGAV
  • DKFZp686A08142
  • MSK8
  • CD51
  • VNRA
UniProt Number
UniProt Summary FUNCTION: SwissProt: P06756 # The alpha-V integrins are receptors for vitronectin, cytotactin, fibronectin, fibrinogen, laminin, matrix metalloproteinase-2, osteopontin, osteomodulin, prothrombin, thrombospondin and von Willebrand factor. They recognize the sequence R-G-D in a wide array of ligands. In case of HIV-1 infection, the interaction with extracellular viral Tat protein seems to enhance angiogenesis in Kaposi's sarcoma lesions.
SIZE: 1048 amino acids; 116038 Da
SUBUNIT: Heterodimer of an alpha and a beta subunit. The alpha subunit is composed of an heavy and a light chain linked by a disulfide bond. Alpha-V associates with either beta-1, beta-3, beta-5, beta-6 or beta-8 subunit. Interacts with HIV-1 Tat.
SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.
SIMILARITY: SwissProt: P06756 ## Belongs to the integrin alpha chain family. & Contains 7 FG-GAP repeats.
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage Conditions Maintain at 2-8°C in undiluted aliquots for up to 6 months.
Packaging Information
Material Size 100 µg
Transport Information
Supplemental Information
Specifications

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