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Rb X Pan Synuclein

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货号：AB5464

品牌：Millipore 密理博

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重要规格表

Species Reactivity Key Applications Host Format Antibody Type
H, R WB, IH(P) Rb Serum Polyclonal Antibody
Description
Catalogue Number AB5464
Brand Family Chemicon®
Trade Name
  • Chemicon
Description Anti-Synuclein Antibody, pan
References
Product Information
Format Serum
Presentation Rabbit serum. Lyophilized. Contains no preservative. Reconstitute with 50 μL of sterile distilled water. Centrifuge if necessary to remove any residue.
Applications
Application Detect Synuclein using this Anti-Synuclein Antibody, pan validated for use in WB, IH(P).
Key Applications
  • Western Blotting
  • Immunohistochemistry (Paraffin)
Application Notes Western blot: 1:1,000.

Immunohistochemistry: 1:1,000 on frozen and paraffin embedded tissue.

Optimal working dilutions must be determined by end user.
Biological Information
Immunogen Peptide corresponding to the amino acids 11-26 of human a, b, and g (82%)-synuclein protein. The peptide was chosen so that the antibody would recognize all three forms of synuclein.
Host Rabbit
Specificity Pan synuclein. Initial testing by immunohistochemistry indicates that the antibody staining pattern overlaps alpha, beta, and gamma-synuclein maps.
Species Reactivity
  • Human
  • Rat
Antibody Type Polyclonal Antibody
Entrez Gene Number
Entrez Gene Summary The protein encoded by this gene is highly homologous to alpha-synuclein. These proteins are abundantly expressed in the brain and putatively inhibit phospholipase D2 selectively. The encoded protein, which may play a role in neuronal plasticity, is abundant in neurofibrillary lesions of patients with Alzheimer disease. This protein has been shown to be highly expressed in the substantia nigra of the brain, a region of neuronal degeneration in patients with Parkinson disease; however, no direct relation to Parkinson disease has been established. Two transcript variants encoding the same protein have been found for this gene.
Gene Symbol
  • SNCA
  • PD1
  • alpha-synuclein
  • NACP
  • PARK4
  • MGC110988
  • PARK1
  • Alpha-synuclein
UniProt Number
UniProt Summary FUNCTION: SwissProt: Q16143 # Non-amyloid component of senile plaques found in Alzheimer disease. Could act as a regulator of SNCA aggregation process. Protects neurons from staurosporine and 6 hydroxy dopamine (6OHDA)-stimulated caspase activation in a p53-dependent manner. Contributes to restore the SNCA anti-apoptotic function abolished by 6OHDA. Not found in the Lewy bodies associated with Parkinson disease.
SIZE: 134 amino acids; 14288 Da
SUBCELLULAR LOCATION: Cytoplasm.
TISSUE SPECIFICITY: Expressed predominantly in brain; concentrated in presynaptic nerve terminals.
PTM: Phosphorylated. Phosphorylation by G-protein coupled receptor kinases (GRK) is more efficient than phosphorylation by CK1, CK2 and CaM-kinase II.
DISEASE: SwissProt: Q16143 # Brain iron accumulation type 1 (NBIA1, also called Hallervorden-Spatz syndrome), a rare neuroaxonal dystrophy, is histologically characterized by axonal spheroids, iron deposition, Lewy body (LB)-like intraneuronal inclusions, glial inclusions and neurofibrillary tangles. SNCB is found in spheroids but not in inclusions.
SIMILARITY: SwissProt: Q16143 ## Belongs to the synuclein family.
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage Conditions Maintain lyophilized material at -20°C to -70°C for up to 6 months. After reconstitution maintain frozen at -20°C in undiluted aliquots for up to 6 months. Avoid repeated freeze/thaw cycles.
Packaging Information
Material Size 50 µL
Transport Information
Supplemental Information
Specifications

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