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Rb X gamma Synuclein

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货号：AB5466

品牌：Millipore 密理博

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Replacement Information

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重要规格表

Species Reactivity Key Applications Host Format Antibody Type
H, R WB, IHC Rb Serum Polyclonal Antibody
Description
Catalogue Number AB5466
Replaces 04-1050
Brand Family Chemicon®
Trade Name
  • Chemicon
Description Anti-Synuclein γ Antibody
References
Product Information
Format Serum
Presentation Rabbit serum. Lyophilized. Contains no preservative. Reconstitute with 50 μL of sterile distilled water. Centrifuge if necessary to remove any residue.
Applications
Application This Anti-Synuclein Antibody, γ is validated for use in WB, IH for the detection of Synuclein.
Key Applications
  • Western Blotting
  • Immunohistochemistry
Application Notes Western blot: 1:500-1:1,000.

Immunohistochemistry: 1:1,000 on frozen tissue.

Optimal working dilutions must be determined by end user.
Biological Information
Immunogen Peptide corresponding to the amino acids 114-127 of human gamma synuclein protein.
Host Rabbit
Specificity Gamma synuclein. The immunizing peptide was chosen to reduce cross-reactivity of AB6466 with a and b-synuclein. Immunohistochemical and Western blot analysis of human brain indicates a high level of specificity.
Species Reactivity
  • Human
  • Rat
Antibody Type Polyclonal Antibody
Entrez Gene Number
Entrez Gene Summary Synuclein-gamma is a member of the synuclein family of proteins which are believed to be involved in the pathogenesis of neurodegenerative diseases. High levels of SNCG have been identified in advanced breast carcinomas suggesting a correlation between overexpression of SNCG and breast tumor development.
Gene Symbol
  • SNCG
  • PERSYN
  • persyn
  • Persyn
  • synoretin
  • BCSG1
  • Synoretin
  • Gamma-synuclein
  • SR
  • PRSN
UniProt Number
UniProt Summary FUNCTION: SwissProt: O76070 # Plays a role in neurofilament network integrity. May be involved in modulating axonal architecture during development and in the adult. In vitro, increases the susceptibility of neurofilament-H to calcium-dependent proteases (By similarity). May also function in modulating the keratin network in skin. Activates the MAPK and Elk-1 signal transduction pathway (By similarity).
SIZE: 127 amino acids; 13331 Da
SUBUNIT: May be a centrosome-associated protein.
SUBCELLULAR LOCATION: Cytoplasm, perinuclear region. Centrosome. Spindle. Note=Associated with centrosomes in several interphase cells. In mitotic cells, localized to the poles of the spindle.
TISSUE SPECIFICITY: Highly expressed in brain, particularly in the substantia nigra. Also expressed in the corpus callosum, heart, skeletal muscle, ovary, testis, colon and spleen. Weak expression in pancreas, kidney and lung.
PTM: Phosphorylated. Phosphorylation by GRK5 appears to occur on residues distinct from the residue phosphorylated by other kinases.
DISEASE: SwissProt: O76070 # Brain iron accumulation type 1 (NBIA1, also called Hallervorden-Spatz syndrome), a rare neuroaxonal dystrophy, is histologically characterized by axonal spheroids, iron deposition, Lewy body (LB)-like intraneuronal inclusions, glial inclusions and neurofibrillary tangles. SNCG is found in spheroids but not in inclusions.
SIMILARITY: SwissProt: O76070 ## Belongs to the synuclein family.
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage Conditions Maintain lyophilized material at -20°C to -70°C for up to 6 months. After reconstitution maintain frozen at -20°C in undiluted aliquots for up to 6 months. Avoid repeated freeze/thaw cycles.
Packaging Information
Material Size 50 µL
Transport Information
Supplemental Information
Specifications

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