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Rb X B3AR

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货号：AB5122

品牌：Millipore 密理博

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重要规格表

Species Reactivity Key Applications Host Format Antibody Type
H ELISA, IHC, WB Rb Affinity Purified Polyclonal Antibody
Description
Catalogue Number AB5122
Brand Family Chemicon®
Trade Name
  • Chemicon
Description Anti-Adrenergic Receptor Antibody, β 3
References
Product Information
Format Affinity Purified
Presentation Affinity Purified immunoglobulin. Liquid in PBS containing 0.1% BSA
Applications
Application Anti-Adrenergic Receptor Antibody, β 3 detects level of Adrenergic Receptor & has been published & validated for use in ELISA, IH & WB.
Key Applications
  • ELISA
  • Immunohistochemistry
  • Western Blotting
Application Notes Western blot: 1-10 μg/mL using Chemiluminescence technique

ELISA: 1:10,000 - 100,000

Immunohistochemistry: 2-20 μg in formaldehyde fixed tissue.

Optimal working dilutions must be determined by end user.
Biological Information
Immunogen A 19 aa sequence at the C-terminus of the human B3AR, splce variant 3 (Emorine et al., 1989; Grannenman et al., 1992; Van Spronsen et al., 1993; Lelias et al., 1993). Control peptide is available under catalog number AG388.
Concentration Please refer to the Certificate of Analysis for the lot-specific concentration.
Host Rabbit
Specificity Human beta 3 adrenergic receptor (B3AR) is a member of the G-protein coupled receptor superfamily. They typically contain 7 transmembrane domains (Barak et al., 1995) Human B3AR is 408 aa membrane protein (Emorine et al., 1989; Grannenman et al., 1992; Van Spronsen et al., 1993; Lelias et al., 1993).
Species Reactivity
  • Human
Antibody Type Polyclonal Antibody
Entrez Gene Number
Entrez Gene Summary The ADRB3 gene product, beta-3-adrenergic receptor, is located mainly in adipose tissue and is involved in the regulation of lipolysis and thermogenesis. Beta adrenergic receptors are involved in the epenephrine and norepinephrine-induced activation of adenylate cyclase through the action of G proteins.
Gene Symbol
  • ADRB3
  • ADRB3R
  • B3AR
  • BETA3AR
UniProt Number
UniProt Summary FUNCTION: SwissProt: P13945 # Beta-adrenergic receptors mediate the catecholamine- induced activation of adenylate cyclase through the action of G proteins. Beta-3 is involved in the regulation of lipolysis and thermogenesis.
SIZE: 408 amino acids; 43519 Da
SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
TISSUE SPECIFICITY: Expressed mainly in adipose tissues.
SIMILARITY: SwissProt: P13945 ## Belongs to the G-protein coupled receptor 1 family.
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage Conditions Maintain frozen at -20°C in undiluted aliquots for up to 6 months after date of receipt. Avoid repeated freeze/thaw cycles.
Packaging Information
Material Size 50 µg
Transport Information
Supplemental Information
Specifications

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