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Rb X Melanocortin Receptor-1

市场价：: 0.00

促销价：: ¥0.00

货号：AB5126

品牌：Millipore 密理博

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北京朝阳

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EA (预计3-5工作日到货)

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重要规格表

Species Reactivity	Key Applications	Host	Format	Antibody Type
M	ELISA, WB	Rb	Affinity Purified	Polyclonal Antibody

Description
Catalogue Number	AB5126
Brand Family	Chemicon®
Trade Name	Chemicon
Description	Anti-Melanocortin Receptor-1 Antibody

References

Product Information
Format	Affinity Purified
Presentation	Affinity Purified immunoglobulin. Liquid in PBS, 0.1% BSA and 0.05% sodium azide.

Applications
Application	Anti-Melanocortin Receptor-1 Antibody is an antibody against Melanocortin Receptor-1 for use in ELISA & WB.
Key Applications	ELISA Western Blotting
Application Notes	Western blot: 1-10 μg/mL using Chemiluminescence technique ELISA: 1:10,000 - 100,000 Optimal working dilutions must be determined by end user.

Biological Information
Immunogen	A 21 mer peptide (designated MCR11) from the 3rd cytoplasmic domain of mouse MC1-R.
Concentration	Please refer to the Certificate of Analysis for the lot-specific concentration.
Host	Rabbit
Specificity	Melanocyte Stimulating Hormone Receptor (MSH-R), also called Melanotropin Receptor, or Melanocortin-1 Receptor (MC1-R), is a 315 aa transmembrane protein belonging to the family 1 of G-Protein coupled receptors. It is a receptor for MSH (a, b, g) and ACTH. Its activity is mediated by G-proteins that activate adenylate cyclase. It is found in Melanocytes and corticoadrenal tissue as well as various tissues like adrenal gland, leukocytes, lung, lymph node, ovary, testis, pituitary, placenta, spleen and uterus. Mouse MSH-R. Reactivity with other species has not been confirmed. The immunogen sequence shows 70% homology with human, 66% with bovine, sheep and horse, and 60% with canine.
Species Reactivity	Mouse
Antibody Type	Polyclonal Antibody
Entrez Gene Number	NM_002386.2
Entrez Gene Summary	This intronless gene encodes the receptor protein for melanocyte-stimulating hormone (MSH). The encoded protein, a seven pass transmembrane G protein coupled receptor, controls melanogenesis. Two types of melanin exist: red pheomelanin and black eumelanin. Gene mutations that lead to a loss in function are associated with increased pheomelanin production, which leads to lighter skin and hair color. Eumelanin is photoprotective but pheomelanin may contribute to UV-induced skin damage by generating free radicals upon UV radiation. Binding of MSH to its receptor activates the receptor and stimulates eumelanin synthesis. This receptor is a major determining factor in sun sensitivity and is a genetic risk factor for melanoma and non-melanoma skin cancer. Over 30 variant alleles have been identified which correlate with skin and hair color, providing evidence that this gene is an important component in determining normal human pigment variation.
Gene Symbol	MC1R MSHR MSH-R MGC14337 MC1-R
UniProt Number	Q01726
UniProt Summary	FUNCTION: SwissProt: Q01726 # Receptor for MSH (alpha, beta and gamma) and ACTH. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. SIZE: 317 amino acids; 34706 Da SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein. TISSUE SPECIFICITY: Melanocytes and corticoadrenal tissue. SIMILARITY: SwissProt: Q01726 ## Belongs to the G-protein coupled receptor 1 family.

Physicochemical Information

Dimensions

Materials Information

Toxicological Information

Safety Information according to GHS

Safety Information

Product Usage Statements
Usage Statement	Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Storage and Shipping Information
Storage Conditions	Can be refrigerated at 2-8°C in undiluted aliquots for short term use. Maintain frozen at -20°C in undiluted aliquots for up to 12 months.

Packaging Information
Material Size	50 µg

Transport Information

Supplemental Information

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