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Ms X Hu C-Myc

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货号：CBL434

品牌：Millipore 密理博

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重要规格表

Species Reactivity Key Applications Host Format Antibody Type
H, M ELISA, IP, WB M Purified Monoclonal Antibody
Description
Catalogue Number CBL434
Brand Family Chemicon®
Trade Name
  • Chemicon
Description Anti-c-myc Antibody, clone 3C7
References
Product Information
Format Purified
Presentation The monoclonal is presented at a concentration of 100μg/1ml in phosphate buffered saline containing 10mM sodium azide and 1mg/ml bovine serum albumin. We recommend that each laboratory determine an optimum working titre for use in its particular application.
Applications
Application Detect c-myc also known as Proto-oncogene c-Myc with Anti-c-myc Antibody, clone 3C7 (Mouse Monoclonal Antibody), that has been demonstrated to work in ELISA, IP & WB.
Key Applications
  • ELISA
  • Immunoprecipitation
  • Western Blotting
Application Notes Western blotting

Immunoprecipitation

Immunoassay detection of c-myc

Optimal working dilutions must be determined by the end user.
Biological Information
Immunogen Synthetic peptide: Cys-Ser-Thr-Ser-Ser-Leu-Tyr-Leu-Gln-Asp-Leu-Ser-Ala-Ala-Ala-Ser-Glu-Cys selected from the human c-myc sequence (amino acids (171-188). The peptide was conjugated to keyhole limpet haemocyanin.
Epitope a.a. 171-188
Clone 3C7
Host Mouse
Specificity In immunoblotting this antibody detects one major band at 62-64 kDa which can be blocked by pre-incubation with the immunizing peptide. In immunoprecipitation the antibody detects a 62 kDa band from cell lysates.

KNOWN SPECIES CROSS REACTIVITY: This antibody is known to cross react with mouse c-myc
Isotype IgG1
Species Reactivity
  • Human
  • Mouse
Antibody Type Monoclonal Antibody
Entrez Gene Number
Entrez Gene Summary The protein encoded by this gene is a multifunctional, nuclear phosphoprotein that plays a role in cell cycle progression, apoptosis and cellular transformation. It functions as a transcription factor that regulates transcription of specific target genes. Mutations, overexpression, rearrangement and translocation of this gene have been associated with a variety of hematopoietic tumors, leukemias and lymphomas, including Burkitt lymphoma. There is evidence to show that alternative translation initiations from an upstream, in-frame non-AUG (CUG) and a downstream AUG start site result in the production of two isoforms with distinct N-termini. The synthesis of non-AUG initiated protein is suppressed in Burkitt's lymphomas, suggesting its importance in the normal function of this gene.
Gene Symbol
  • MYC
  • C-MYC
  • c-Myc
UniProt Number
UniProt Summary FUNCTION: SwissProt: P01106 # Participates in the regulation of gene transcription. Binds DNA both in a non-specific manner and also specifically to recognizes the core sequence 5'-CAC[GA]TG-3'. Seems to activate the transcription of growth-related genes.
SIZE: 439 amino acids; 48804 Da
SUBUNIT: Efficient DNA binding requires dimerization with another bHLH protein. Binds DNA as a heterodimer with MAX. Interacts with TAF1C and SPAG9. Interacts with PARP10. Interacts with JARID1A and JARID1B.
SUBCELLULAR LOCATION: Nucleus.
PTM: Phosphorylated by PRKDC.
DISEASE: SwissProt: P01106 # Overexpression of MYC is implicated in the etiology of a variety of hematopoietic tumors. & A chromosomal aberration involving MYC may be a cause of a form of B-cell chronic lymphocytic leukemia. Translocation t(8;12)(q24;q22) with BTG1.
SIMILARITY: SwissProt: P01106 ## Contains 1 basic helix-loop-helix (bHLH) domain.
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage Conditions For use within 1 month of purchase store at +4°C, for long term storage aliquot antibody into small volumes and store at -20°C.
Packaging Information
Material Size 100 µg
Transport Information
Supplemental Information
Specifications

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