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Ms X Hu CD49f FITC

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货号：CBL458F

品牌：Millipore 密理博

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重要规格表

Species Reactivity Key Applications Host Format Antibody Type
H FC, IP, IHC M FITC Monoclonal Antibody
Description
Catalogue Number CBL458F
Replaces MAB2254F
Brand Family Chemicon®
Trade Name
  • Chemicon
Description Anti-CD49f Antibody, FITC conjugated, clone 4F10, FITC conjugated
Alternate Names
  • Integrin alpha6
References
Product Information
Format FITC
Presentation Protein A purified immunoglobulin conjugated to fluorescein isothiocyanate (FITC). Liquid in PBS containing 1mg/mL BSA and 10mM sodium azide.
Applications
Application Anti-CD49f Antibody, FITC conjugated, clone 4F10, FITC conjugated is an antibody against CD49fd for use in FC, IP, IH.
Key Applications
  • Flow Cytometry
  • Immunoprecipitation
  • Immunohistochemistry
Application Notes Immunohistological studies on frozen sections

Immunoprecipitation of the laminin receptor

Flow Cytometry: 10 μL per 106

Optimal working dilutions must be determined by the end user.
Biological Information
Immunogen Cell line SW/222 (Human colorectal carcinoma).
Clone 4F10
Host Mouse
Specificity This antibody is specific to CD49f (integrin alpha6) chain) which is expressed on epithelial and endothelial basement membrane. The VLA alpha6 chain, which consists of a single disulfide linked 120 kDa subunit and a small doublet subunit of 25/30 kDa, is noncovalently-associated with the VLA beta-chain (CD29) in VLA-6 or alpha6/beta1 complex or with integrin beta4 chain (alpha6/beta4). The antigen is expressed on platelets, monocytes, thymocytes and T lymphocytes.

FUSION PARTNER: NS1 myeloma cell line
Isotype IgG2b
Species Reactivity
  • Human
Antibody Type Monoclonal Antibody
Entrez Gene Number
Entrez Gene Summary The ITGA6 protein product is the integrin alpha chain alpha 6. Integrins are integral cell-surface proteins composed of an alpha chain and a beta chain. A given chain may combine with multiple partners resulting in different integrins. For example, alpha 6 may combine with beta 4 in the integrin referred to as TSP180, or with beta 1 in the integrin VLA-6. Integrins are known to participate in cell adhesion as well as cell-surface mediated signalling. Two transcript variants encoding different isoforms have been found for this gene.
Gene Symbol
  • ITGA6
  • VLA-6
  • ITGA6B
  • CD49f
UniProt Number
UniProt Summary FUNCTION: SwissProt: P23229 # Integrin alpha-6/beta-1 is a receptor for laminin on platelets. Integrin alpha-6/beta-4 is a receptor for laminin in epithelial cells and it plays a critical structural role in the hemidesmosome.
SIZE: 1130 amino acids; 126619 Da
SUBUNIT: Heterodimer of an alpha and a beta subunit. The alpha subunit is composed of an heavy and a light chain linked by a disulfide bond. Alpha-6 associates with either beta-1 or beta-4. Interacts with HPS5.
SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.
TISSUE SPECIFICITY: Integrin alpha-6/beta-4 is predominantly expressed by epithelia. Isoforms containing segment X1 are ubiquitously expressed. Isoforms containing segment X1X2 are expressed in heart, kidney, placenta, colon, duodenum, myoblasts and myotubes, and in a limited number of cell lines; they are always coexpressed with the ubiquitous isoform containing segment X1. In some tissues (e.g. Salivary gland), isoforms containing cytoplasmic segment A and isoforms containing segment B are detected while in others, only isoforms containing one cytoplasmic segment are found (segment A in epidermis and segment B in kidney).
PTM: Isoforms containing segment A, but not segment B, are the major targets for PMA-induced phosphorylation. Phosphorylation occurs on 'Ser-1103' of isoform alpha-6X1X2A. Phosphorylation is not required for the induction of integrin alpha-6A/beta-1 high affinity but may reduce the affinity for ligand.
DISEASE: "SwissProt: P23229 # Defects in ITGA6 are a cause of epidermolysis bullosa with pyloric atresia (EB-PA) [MIM:226730]; also known as aplasia cutis congenita with gastrointestinal atresia. EB-PA is an autosomal recessive disease characterized by mucocutaneous fragility and gastrointestinal atresia, which most commonly affects the pylorus."
SIMILARITY: SwissProt: P23229 ## Belongs to the integrin alpha chain family. & Contains 7 FG-GAP repeats.
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage Conditions Maintain at 2-8°C for up to 12 months from date of receipt, protected from light. DO NOT FREEZE.
Packaging Information
Material Size 100 assays
Transport Information
Supplemental Information
Specifications

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