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RAGE, GTX (NO PRESERV)-200UL

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货号：AB5484Z

品牌：Millipore 密理博

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重要规格表

Species Reactivity Key Applications Host Format Antibody Type
H ELISA, IH(P) Gt Serum Polyclonal Antibody
Description
Catalogue Number AB5484Z
Brand Family Chemicon®
Trade Name
  • Chemicon
Description Anti-RAGE Antibody, azide free
Alternate Names
  • Advanced glycosylation end product-specific receptor
  • ReceptorforAdvancedGlycosylationEndProducts
Background Information RAGE is a member of the immunoglobulin superfamily of cell surface molecules that binds molecules that have been irreversibly modified by non-enzymatic glycation and oxidation, and are know as advanced glycation end products (AGEs). It is expressed by endothelium, mononuclear phagocytes, neurons and smooth muscle cells. Whereas RAGE is present at high levels during development, especially in the central nervous system, its levels decline during maturity.The increased expression of RAGE is associated with several pathological states, such as diabetic vasculopathy, neuropathy, retinopathy and other disorders, including Alzheimer's disease and immune/inflammatory reactions of the vessel walls. In diabetic tissues, the production of RAGE is due to the overproduction of AGEs that eventually overwhelm the protective properties of RAGE. This results in oxidative stress and endothelial cell dysfunction that leads to vascular disease in diabetics. In the brain, RAGE also binds amyloid beta (Abeta). Because Abeta is overproduced in neurons and vessels in the brains of Alzheimer disease, this leads to the hyperstimulation of RAGE. The RAGE-Abeta interaction is thought to result in oxidative stress leading to neuronal degeneration.
References
Product Information
Format Serum
Presentation Goat serum. Liquid. Contains no preservative.
Applications
Application Anti-RAGE Antibody, azide free detects level of RAGE & has been published & validated for use in ELISA, IH(P).
Key Applications
  • ELISA
  • Immunohistochemistry (Paraffin)
Application Notes Immunohistochemistry on formalin fixed, paraffin embedded tissue sections: > 1:400. The antibody reacts well with human diabetic kidney. The antibody may show better reactivity after performing antigen retrieval by the citrate buffer/pressure cooker method.

ELISA against immunogen peptide: > 1:260,000

Optimal working dilutions must be determined by the end user.
Biological Information
Immunogen Synthetic peptide that corresponds to amino acids 42-59 of the human receptor for advanced glycated end products.
Host Goat
Specificity Specific for receptor for advanced glycosylation end products (RAGE). This antibody immunolabels vessels from diabetic tissues and vessels and neurons from the brains of Alzheimer's Disease (AD) patients in formalin-fixed paraffin sections.
Species Reactivity
  • Human
Antibody Type Polyclonal Antibody
Entrez Gene Number
Gene Symbol
  • AGER
  • RAGE
  • MGC22357
UniProt Number
UniProt Summary FUNCTION: SwissProt: Q15109 # Mediates interactions of advanced glycosylation end products (AGE). These are nonenzymatically glycosylated proteins which accumulate in vascular tissue in aging and at an accelerated rate in diabetes. Receptor for amyloid beta peptide.
SIZE: 404 amino acids; 42803 Da
SUBCELLULAR LOCATION: Isoform 1: Cell membrane; Single-pass type I membrane protein. & Isoform 2: Secreted.
TISSUE SPECIFICITY: Endothelial cells.
SIMILARITY: SwissProt: Q15109 ## Contains 2 Ig-like C2-type (immunoglobulin-like) domains. & Contains 1 Ig-like V-type (immunoglobulin-like) domain.
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage Conditions Maintain at -20°C in undiluted aliquots for up to 6 months after date of receipt. Avoid repeated freeze/thaw cycles.
Packaging Information
Material Size 200 µL
Transport Information
Supplemental Information
Specifications

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