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Urokinase, Human Urine

市场价：: 0.00

促销价：: ¥0.00

货号：CC4000

品牌：Millipore 密理博

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北京朝阳

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EA (预计3-5工作日到货)

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Replacement Information

重要规格表

Key Applications	Entrez Gene Number	Species	Uni Prot Number
ACT	NM_002658.2	Human	P00749

Description
Catalogue Number	CC4000
Brand Family	Chemicon®
Trade Name	Chemicon
Description	Urokinase-type Plasminogen Activator
Overview	A thrombolytic agent that converts plasminogen to plasmin. A mixture of high molecular weight and low molecular weight urokinase.
Alternate Names	uPA

References

Product Information
Presentation	Lyophilized from 200 mM manitol, 100 mM NaCl, 50 mM Tris-HCl, pH 7.5 and 0.1 % PEG.

Applications
Key Applications	Activity Assay

Biological Information
Purity	Over 98%SDS-PAGE: High molecular weight urokinase (54 kD) 40% Low molecular weight urokinase (33 kD) 50% Transitory forms of urokinase 10%
Source	Prepared from urine of healthy individuals
Entrez Gene Number	NM_002658.2
Entrez Gene Summary	This gene encodes a serine protease involved in degradation of the extracellular matrix and possibly tumor cell migration and proliferation. A specific polymorphism in this gene may be associated with late-onset Alzheimer disease and also with decreased affinity for fibrin-binding. The protein encoded by this gene converts plasminogen to plasmin by specific cleavage of an Arg-Val bond in plasminogen. This gene's proprotein is cleaved at a Lys-Ile bond by plasmin to form a two-chain derivative in which a single disulfide bond connects the amino-terminal A-chain to the catalytically active, carboxy-terminal B-chain. This two-chain derivative is also called HMW-uPA (high molecular weight uPA). HMW-uPA can be further processed into LMW-uPA (low molecular weight uPA) by cleavage of chain A into a short chain A (A1) and an amino-terminal fragment. LMW-uPA is proteolytically active but does not bind to the uPA receptor.
Gene Symbol	PLAU UPA URK u-PA uPA ATF EC 3.4.21.73 [Contains: Urokinase-type plasminogen activator long chain A Urokinase-type plasminogen activator short chain A Urokinase-type plasminogen activator chain B].
UniProt Number	P00749
UniProt Summary	FUNCTION: SwissProt: P00749 # Specifically cleave the zymogen plasminogen to form the active enzyme plasmin. SIZE: 431 amino acids; 48525 Da SUBUNIT: Found in high and low molecular mass forms. Each consists of two chains, A and B. The high molecular mass form contains a long chain A which is cleaved to yield a short chain A. Binds LRP1B; binding is followed by internalization and degradation. Interacts with MRC2. Interacts with PLAUR. SUBCELLULAR LOCATION: Secreted. TISSUE SPECIFICITY: Expressed in the prostate gland and prostate cancers. PTM: Phosphorylation of Ser-158 and Ser-323 abolishes proadhesive ability but does not interfere with receptor binding. SIMILARITY: SwissProt: P00749 ## Belongs to the peptidase S1 family. & Contains 1 EGF-like domain. & Contains 1 kringle domain. & Contains 1 peptidase S1 domain.

Physicochemical Information

Dimensions

Materials Information

Toxicological Information

Safety Information according to GHS

Safety Information

Product Usage Statements
Usage Statement	Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Storage and Shipping Information
Storage Conditions	Reconstitute using 200-400 μL dH2O. Store at -20°C. Following reconstitution, aliquot and freeze (-70°C). This product is stable for 2 year as supplied. Stock solutions are stable for up to 6 months at -70°C.

Packaging Information
Material Size	100 µg

Transport Information

Supplemental Information

Specifications

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