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Rb X GABA B Receptor R2 Subunit

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货号：AB5848

品牌：Millipore 密理博

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重要规格表

Species Reactivity Key Applications Host Format Antibody Type
H, R WB Rb Purified Polyclonal Antibody
Description
Catalogue Number AB5848
Brand Family Chemicon®
Trade Name
  • Chemicon
Description Anti-GABA B Receptor R2 Antibody, a.a. 42-54 rat
Background Information The inhibitory neurotransmitter, GABA, acts through two ligand-gated channels, GABA(A) and GABA© receptors and GABA(B), the latter of which acts through a G protein mechanism. GABA(B)R2 is one of the two G-protein coupled receptors for GABA(B) that acts as a heteromeric assembly with GABA(B)R1.
References
Product Information
Format Purified
Presentation Purified immunoglobulin. Liquid. Buffer = PBS containing 0.02% sodium azide.
Applications
Application This Anti-GABA B Receptor R2 Antibody, a.a. 42-54 rat is validated for use in WB for the detection of GABA B Receptor R2.
Key Applications
  • Western Blotting
Application Notes Immunoblotting: 1:500-1:1,000. Membrane preparations with proteinase inhibitors are recommended. Whole rat brain membrane preparations. The antibody detects a ~105kDa band under standard western conditions. The immunogen used is 100% conserved in human by sequence analysis; other species have not been examined for reactivity or homology.

Optimal working dilutions must be determined by end user.
Biological Information
Immunogen peptide residues 42-54 of the rat 105 kDa GABA(b)R2 protein
Epitope a.a. 42-54 rat
Concentration Please refer to the Certificate of Analysis for the lot-specific concentration.
Host Rabbit
Specificity GABAB Receptor R2 subunit, N-terminus. No reactivity with GABABR1 has been detected.
Species Reactivity
  • Human
  • Rat
Antibody Type Polyclonal Antibody
Entrez Gene Number
Entrez Gene Summary B-type receptors for the neurotransmitter GABA (gamma-aminobutyric acid) inhibit neuronal activity through G protein-coupled second-messenger systems, which regulate the release of neurotransmitters and the activity of ion channels and adenylyl cyclase. See GABBR1 (MIM 603540) for additional background information on GABA-B receptors.[supplied by OMIM]
Gene Symbol
  • GABBR2
  • HRIHFB2099
  • OTTHUMP00000063797
  • GPRC3B
  • GPR51
  • HG20
  • Gb2
  • FLJ36928
  • GABA-B-R2
  • GABABR2
UniProt Number
UniProt Summary FUNCTION: SwissProt: O75899 # Receptor for GABA. The activity of this receptor is mediated by G-proteins that inhibit adenylyl cyclase activity, stimulates phospholipase A2, activates potassium channels, inactivates voltage-dependent calcium-channels and modulates inositol phospholipids hydrolysis. Plays a critical role in the fine-tuning of inhibitory synaptic transmission. Pre-synaptic GABA-B-R inhibit neurotransmitter release by down-regulating high- voltage activated calcium channels, whereas postsynaptic GABA-B-R decrease neuronal excitability by activating a prominent inwardly rectifying potassium (Kir) conductance that underlies the late inhibitory postsynaptic potentials. Not only implicated in synaptic inhibition but also in hippocampal long-term potentiation, slow wave sleep, muscle relaxation and antinociception.
SIZE: 941 amino acids; 105821 Da
SUBUNIT: Heterodimer of GABA-B-R1 and GABA-B-R2. Neither of which is effective on its own and homodimeric assembly does not seem to happen. Interacts with ATF4 via its C-terminal region.
SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein. Note=Moreover coexpression of GABA-B-R1 and GABA-B-R2 appears to be a prerequisite for maturation and transport of GABA-B-R1 to the plasma membrane.
TISSUE SPECIFICITY: Highly expressed in brain, especially in cerebral cortex, thalamus, hippocampus, frontal, occipital and temporal lobe, occipital pole and cerebellum, followed by corpus callosum, caudate nucleus, spinal cord, amygdala and medulla. Weakly expressed in heart, testis and skeletal muscle.
DOMAIN: SwissProt: O75899 Alpha-helical parts of the C-terminal intracellular region mediate heterodimeric interaction with GABA-B receptor 1.
SIMILARITY: Belongs to the G-protein coupled receptor 3 family. GABA-B receptor subfamily.
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage Conditions Maintain frozen at -20°C in undiluted aliquots for up to 6 months. Avoid repeated freeze/thaw cycles.
Packaging Information
Material Size 100 µg
Transport Information
Supplemental Information
Specifications

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