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Rb X Glutamate Receptor 1 phosphoSer845

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货号：AB5849-25UL

品牌：Millipore 密理博

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重要规格表

Species Reactivity Key Applications Host Format Antibody Type
R WB Rb Affinity Purified Polyclonal Antibody
Description
Catalogue Number AB5849-25UL
Brand Family Chemicon®
Trade Name
  • Chemicon
Description Anti-Glutamate Receptor 1 Antibody, phosphoSer 845
Alternate Names
  • GluR1
References
Product Information
Format Affinity Purified
Presentation Affinity purified immunoglobulin. Liquid in 10 mM HEPES, pH 7.5, with 150 mM NaCl, 100 μg/mL BSA and 50% glycerol.
Applications
Application This Anti-Glutamate Receptor 1 Antibody, phosphoSer 845 is validated for use in WB for the detection of Glutamate Receptor 1.
Key Applications
  • Western Blotting
Application Notes Western blot: 1:500-1:1,000

Optimal working dilutions must be determined by the end user.
Biological Information
Immunogen Synthetic peptide corresponding to amino acids surrounding the phosphoSer845 of rat GluR1.
Epitope phosphoSer 845
Host Rabbit
Specificity Glutamate Receptor 1 [GluR1], phosphoSer845. The antibody recognizes a protein of 100 kDa corresponding to GluR1 phosphorylated at Ser845 in rat brain extracts. Immunolabeling is blocked by the phosphopeptide used as the immunogen but not non-phosphopeptide.
Species Reactivity
  • Rat
Antibody Type Polyclonal Antibody
Entrez Gene Number
Entrez Gene Summary Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. These receptors are heteromeric protein complexes with multiple subunits, each possessing transmembrane regions, and all arranged to form a ligand-gated ion channel. The classification of glutamate receptors is based on their activation by different pharmacologic agonists. This gene belongs to a family of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate (AMPA) receptors. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Gene Symbol
  • GRIA1
  • GluR-K1
  • GLURA
  • HBGR1
  • GluR-A
  • GluR-1
  • GLUH1
  • GLUR1
  • MGC133252
Modifications
  • Phosphorylation
UniProt Number
UniProt Summary FUNCTION: SwissProt: P42261 # Ionotropic glutamate receptor. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L- glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist.
SIZE: 906 amino acids; 101506 Da
SUBUNIT: Homotetramer or heterotetramer of pore-forming glutamate receptor subunits. Tetramers may be formed by the dimerization of dimers. Interacts with DLG1 via its C-terminus. Interacts with CACNG2 and RASGRF2 (By similarity).
SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane protein (By similarity). Note=Interaction with CACNG2 promotes cell surface expression (By similarity).
TISSUE SPECIFICITY: Widely expressed in brain.
PTM: Palmitoylated. Depalmitoylated upon glutamate stimulation. Cys-603 palmitoylation leads to Golgi retention and decreased cell surface expression. In contrast, Cys-829 palmitoylation does not affect cell surface expression but regulates stimulation-dependent endocytosis (By similarity).
SIMILARITY: SwissProt: P42261 ## Belongs to the glutamate-gated ion channel (TC 1.A.10) family.
MISCELLANEOUS: The postsynaptic actions of Glu are mediated by a variety of receptors that are named according to their selective agonists. This receptor binds AMPA (quisqualate) > glutamate > kainate.
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage Conditions Maintain at -20°C in undiluted for up to 6 months after date of receipt. Avoid repeated freeze/thaw cycles. Do not store in a self-defrosting freezer.
Packaging Information
Material Size 25 µL
Transport Information
Supplemental Information
Specifications

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