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Rb X VRL-1

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货号：AB5398P

品牌：Millipore 密理博

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重要规格表

Species Reactivity Key Applications Host Format Antibody Type
R WB, ICC, IHC Rb Affinity Purified Polyclonal Antibody
Description
Catalogue Number AB5398P
Brand Family Chemicon®
Trade Name
  • Chemicon
Description Anti-Vanilloid Receptor Like Protein Antibody, pain, CT
Alternate Names
  • VRL-1
References
Product Information
Format Affinity Purified
Presentation Affinity purified immunoglobulin. Lyophilized. Contains no preservative. Reconstitute with 20 μL of sterile distilled water. Centrifuge if necessary to remove any residue.
Applications
Application Anti-Vanilloid Receptor Like Protein Antibody, pain, C-terminus is an antibody against Vanilloid Receptor Like Protein for use in WB, IC, IH.
Key Applications
  • Western Blotting
  • Immunocytochemistry
  • Immunohistochemistry
Application Notes Western blot: 0.5-1 μg/mL

Immunohistochemistry: 0.5-1.0 μg/mL on rat dorsal root ganglia and spinal cord.

Immunocytochemistry: 0.5-1.0 μg/mL on rat dorsal root ganglia and spinal cord.

Optimal working dilutions must be determined by end user.
Biological Information
Immunogen Peptide corresponding to the C-terminal 18 amino acids of the rat VRL-1 protein sequence (Acc#: AAD26364). This immunogen sequence is 100% conserved in the mouse growth factor regulated calcium channel (Acc#: AB021665)
Epitope C-terminus
Concentration Please refer to the Certificate of Analysis for the lot-specific concentration.
Host Rabbit
Specificity Vanilloid receptor like protein 1 (VRL-1). Immunohistochemical analysis of rat dorsal root ganglia and spinal cord indicates specific staining in a subpopulation of sensory neurons.
Species Reactivity
  • Rat
Antibody Type Polyclonal Antibody
Entrez Gene Number
Entrez Gene Summary This gene encodes an ion channel that is activated by high temperatures above 52 degrees Celsius. The protein may be involved in transduction of high-temperature heat responses in sensory ganglia. It is thought that in other tissues the channel may be activated by stimuli other than heat.
Gene Symbol
  • TRPV2
  • VRL
  • TrpV2
  • VRL-1
  • OTRPC2
  • MGC12549
  • VRL1
Non-Reactive Species
  • Human
UniProt Number
UniProt Summary FUNCTION: SwissProt: Q9Y5S1 # Calcium-permeable, non-selective cation channel with an outward rectification. Seems to be regulated, at least in part, by IGF-I, PDGF and neuropeptide head activator. May transduce physical stimuli in mast cells. Activated by temperatures higher than 52 degrees Celsius; is not activated by vanilloids and acidic pH.
SIZE: 764 amino acids; 85981 Da
SUBUNIT: Homotetramer (Probable). Interacts with a cAMP-dependent protein kinase type II regulatory subunit (PRKAR2A or PRKAR2B) and ACBD3. Interacts with RGA (By similarity).
SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein (By similarity). Cytoplasm (By similarity). Melanosome. Note=Translocates from the cytoplasm to the plasma membrane upon ligand stimulation (By similarity). Identified by mass spectrometry in melanosome fractions from stage I to stage IV.
PTM: N-glycosylated (By similarity). & Phosphorylated by PKA (By similarity).
SIMILARITY: SwissProt: Q9Y5S1 ## Belongs to the transient receptor family. TrpV subfamily. & Contains 3 ANK repeats.
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage Conditions Maintain lyophilized material at -20°C to -70°C for up to 6 months after date of receipt. After reconstitution maintain frozen at -20°C in undiluted aliquots for up to 6 months. Glycerol (1:1) can be assed to additional stability. Avoid repeated freeze/thaw cycles.
Packaging Information
Material Size 20 µg
Transport Information
Supplemental Information
Specifications

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