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Rb X Drosophila BMAL1

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货号：AB5436P

品牌：Millipore 密理博

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重要规格表

Species Reactivity Key Applications Host Format Antibody Type
Dr ELISA, WB Rb Affinity Purified Polyclonal Antibody
Description
Catalogue Number AB5436P
Brand Family Chemicon®
Trade Name
  • Chemicon
Description Anti-Brain and Muscle ARNT-Like 1 Antibody
Alternate Names
  • BMAL1
  • MOP3/CYCLE
References
Product Information
Format Affinity Purified
Presentation Affinity purified immunoglobulin. Liquid in phosphate buffered saline, pH 7.4, containing 0.1% BSA and 0.1% sodium azide.
Applications
Application Anti-Brain & Muscle ARNT-Like 1 Antibody is a Rabbit Polyclonal Antibody for detection of Brain & Muscle ARNT-Like 1 also known as BMAL1, MOP3/CYCLE & has been validated in ELISA & WB.
Key Applications
  • ELISA
  • Western Blotting
Application Notes Western blot: 1-10 μg/mL using ECL.

ELISA: 0.5-1 μg/mL using 1 μg/mL control peptide per well.

Optimal working dilutions must be determined by the end user.
Biological Information
Immunogen A 22 amino acid peptide of drosophila BMAL1 (Darlington et al. 1998; Rutila et al. 1998; Bae et al. 1998). Gene accession # 3219728.
Concentration Please refer to the Certificate of Analysis for the lot-specific concentration.
Host Rabbit
Specificity Recognizes drosophila BMAL1. The immunogen shows no significant sequence homology with mammalian Clock or Per proteins. Significant homology is seen with mammalian USF's (Upstream Stimulatory Factors 1 and 2) and human and mouse BMAL1 and ARNTs.

SPECIES REACTIVITIES: The immunogen sequence has no homology with mammalian Clock or Per proteins. Reactivity with other species has not been confirmed.
Species Reactivity
  • Drosophila
Antibody Type Polyclonal Antibody
Entrez Gene Number
Entrez Gene Summary The protein encoded by this gene is a basic helix-loop-helix protein that forms a heterodimer with CLOCK. This complex binds an E-box upstream of the PER1 gene, activating this gene and possibly other circadian rhythym-associated genes. Three transcript variants encoding two different isoforms have been found for this gene.
Gene Symbol
  • ARNTL
  • BMAL1
  • MOP3
  • BMAL1c
  • TIC
  • PASD3
  • JAP3
  • MGC47515
UniProt Number
UniProt Summary FUNCTION: SwissProt: O00327 # BMAL1-CLOCK heterodimers activate E-box element (3'- CACGTG-5') transcription of a number of proteins of the circadian clock. This transcription is inhibited in a feedback loop by PER, and also by CRY proteins (By similarity).
SIZE: 626 amino acids; 68762 Da
SUBUNIT: Component of the circadian clock oscillator which includes the CRY proteins, CLOCK or NPAS2, BMAL1 or BMAL2, CSNK1D and/or CSNK1E, TIMELESS and the PER proteins. Efficient DNA binding requires dimerization with another bHLH protein. Heterodimerization with CLOCK is required for E-box-dependent transactivation, for CLOCK nuclear translocation and degradation, and, for phosphorylation of both CLOCK and BMAL1. Interaction with PER and CRY proteins requires translocation to the nucleus. Interaction of the CLOCK-BMAL1 heterodimer with PER or CRY inhibits transcription activation. Interacts with HSP90; with AHR in vitro, but not in vivo.
SUBCELLULAR LOCATION: Nucleus (By similarity).
TISSUE SPECIFICITY: Highly expressed in the adult brain, skeletal muscle and heart.
PTM: Phosphorylated upon dimerization with CLOCK (By similarity). & Sumoylated on Lys-259 upon dimerization with CLOCK (By similarity).
SIMILARITY: SwissProt: O00327 ## Contains 1 basic helix-loop-helix (bHLH) domain. & Contains 1 PAC (PAS-associated C-terminal) domain. & Contains 2 PAS (PER-ARNT-SIM) domains.
MISCELLANEOUS: CLOCK-BMAL1 double mutations within the PAS domains result in syngernistic desensitization to high levels of CRY on repression of CLOCK-BMAL1 transcriptional activity of PER1 and, disrupt circadian rhythmicity.
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage Conditions Maintain at -20°C in undiluted aliquots for up to 6 months. Avoid repeated freeze/thaw cycles.
Packaging Information
Material Size 50 µg
Transport Information
Supplemental Information
Specifications

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