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Rb X HuD

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货号：AB5971

品牌：Millipore 密理博

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Replacement Information
Replacement Information AB05644 is a recommended replacement for AB5971

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重要规格表

Species Reactivity Key Applications Host Format Antibody Type
H, R, M WB Rb Purified Polyclonal Antibody
Description
Catalogue Number AB15644
Replaces AB5971
Description Anti-HuD Antibody
Alternate Names
  • ELAV (embryonic lethal, abnormal vision, Drosophila)-like 4 (Hu antigen D)
  • ELAV-like 4
  • Embryonic lethal, abnormal vision, Drosophila, homolog of, like-4
  • Hu-antigen D
  • Paraneoplastic encephalomyelitis antigen HuD
Background Information ELAV-like protein 4 (ELAVL4) also know as Human neuron-specific RNA-binding protein HuD belongs to the family of Hu proteins and consists of two N-terminal RNA recognition motifs (RRM1 and -2), a hinge region, and a C-terminal RRM (RRM3). Characteristically, these homologs all contain three RNA recognition motifs (RRM), and they specifically bind to AU-rich elements (ARE) in the 3'-untranslated region of mRNAs transcripts. ARE sites target mRNA for rapid degradation and thereby regulate the expression levels of genes involved in cell growth and differentiation. HuD is localized and expressed in brain tissue immediately after neuroblastic differentiation into neurons and is necessary for neuronal differentiation and maintenance. HuD has been linked with the disease, paraneoplastic encephalomyelitis sensory neuropathy, which is associated with small cell lung cancer and is characterized by dementia, sensory loss, and other neurological disabilities.
References
Product Information
Format Purified
Control
  • Human Brain lysate
Presentation Purified rabbit polyclonal in buffer containing 0.1M Tris-Glycine (pH7.4) 15mM sodium chloride with 0.05% sodium azide.
Applications
Application This Anti-HuD Antibody is validated for use in WB for the detection of HuD.
Key Applications
  • Western Blotting
Biological Information
Immunogen KLH-conjugated linear peptide a.a. 26-42.
Concentration Please refer to the Certificate of Analysis for the lot-specific concentration.
Host Rabbit
Specificity Antibody recognizes HuD.
Species Reactivity
  • Human
  • Rat
  • Mouse
Species Reactivity Note Tested on human, mouse, and rat. Sequence Homology 100% with rat, mouse, human, primate, dog, cow
Antibody Type Polyclonal Antibody
Entrez Gene Number
Gene Symbol
  • HUD
  • PNEM
  • ELAVL4
  • OTTHUMP00000009612
Purification Method Antigen Affinity Purified
UniProt Number
UniProt Summary FUNCTION: SwissProt: P26378 # May play a role in neuron-specific RNA processing. Protects CDKN1A mRNA from decay by binding to its 3'-UTR (By similarity).
SIZE: 380 amino acids; 41760 Da
SUBUNIT: Component of a TAU mRNP complex, at least composed of IGF2BP1, ELAVL4 and G3BP (By similarity).
TISSUE SPECIFICITY: Brain.
PTM: Methylation at Arg-243 by CARM1 weakens protective binding to the 3'-UTR of CDKN1A mRNA and down-regulates CDKN1A protein expression, thereby maintaining cells in a proliferative state. Methylation is inhibited by NGF, which facilitates neurite outgrowth (By similarity).
DISEASE: SwissProt: P26378 # Paraneoplastic encephalomyelitis sensory neuropathy is associated with small cell lung cancer and is characterized by dementia, sensory loss, and other neurological disabilities. It may result from an immune response primarily directed against a small cell lung tumor antigen which is misdirected against similar antigens expressed in brain.
SIMILARITY: SwissProt: P26378 ## Belongs to the RRM elav family. & Contains 3 RRM (RNA recognition motif) domains.
Molecular Weight Approx. 42 kDa
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Quality Assurance Routinely evaluated by western blot on human brain lysate
Western Blot:
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage Conditions Stable for 1 year at 2-8ºC from date of receipt.
Packaging Information
Material Size 100 µg
Transport Information
Supplemental Information
Specifications

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