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Anti-PI3 Kinase, p110a, rabbit monoclonal

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货号：04-399

品牌：Millipore 密理博

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重要规格表

Species Reactivity Key Applications Host Format Antibody Type
H, Mk, Ca, M, R WB, IP, ICC, IHC, ELISA Rb Affinity Purified Polyclonal Antibody
Description
Catalogue Number 09-482
Replaces 04-399
Description Anti-PI3 Kinase Antibody, p110β
Alternate Names
  • PI3-kinase p110 subunit alpha
  • phosphatidylinositol 3-kinase, catalytic, 110-KD
  • alpha
  • PtdIns-3-kinase p110
  • phosphatidylinositol 3-kinase, catalytic, alpha polypeptide
  • phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit, alpha isoform
  • phosphoinositide-3-kinase, catalytic, alpha polypeptide
Background Information PI3 Kinase (Phosphatidylinositol 3-Kinase) is responsible for phosphorylation of the 3 position of the inositol ring of PI(4,5)P2, to generate PI(3,4,5)P3, a potent second messenger required for survival, signaling, and insulin action. PI3 Kinase is a heterodimeric complex composed of an 85 kDa regulatory subunit and a 110 kDa catalytic subunit. Tyrosine phosphorylation of growth factor receptors creates docking sites for binding of p85 (through its SH2 domains) on the receptors; p85 brings with it p110, which is then proximal to its phospho-lipid substrate on the membrane. PI3 Kinase is also activated by Ras, and by the β:γ subunits of heterotrimeric G-proteins. PI3 Kinase is inhibitable by wortmannin, a useful tool for the study of the PI3 Kinase signaling pathway.
References
Product Information
Format Affinity Purified
Control
  • HEK-293 cell lysate.
Presentation Antigen affinity purified rabbit serum in 0.1M Tris-Glycine (pH7.4), 150mM NaCl, with 0.05% NaN3.
Applications
Application Anti-PI3 Kinase Antibody, p110β is an antibody against PI3 Kinase for use in WB, IP, IC, IH, ELISA.
Key Applications
  • Western Blotting
  • Immunoprecipitation
  • Immunocytochemistry
  • Immunohistochemistry
  • ELISA
Application Notes ELISA:
This antibody was tested and determined to work for ELISA at 0.5 ng/well.
Biological Information
Immunogen KLH-conjugated synthetic linear peptide corresponding to the internal domain of PI3 Kinase, p110β.
Epitope Internal Domain
Concentration Please refer to the Certificate of Analysis for the lot-specific concentration.
Host Rabbit
Specificity Recognizes the internal domain of PI3 Kinase, p110β.
Species Reactivity
  • Human
  • Monkey
  • Canine
  • Mouse
  • Rat
Species Reactivity Note Human. Expected to react with Monkey, Dog, Rat and Mouse based on immunogen sequence homology.
Antibody Type Polyclonal Antibody
Entrez Gene Number
Gene Symbol
  • EC 2.7.1.153
  • MGC142161
  • MGC142163
  • PI3K
  • p110-alpha
Purification Method Affinity Purfied
UniProt Number
UniProt Summary FUNCTION: Phosphorylates PtdIns, PtdIns4P and PtdIns(4,5)P2 with a preference for PtdIns(4,5)P2.

CATALYTIC ACTIVITY: ATP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate = ADP + 1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate.

SUBUNIT STRUCTURE: Heterodimer of a p110 (catalytic) and a p85 (regulatory) subunit. Binds to IRS1 in nuclear extracts. Interacts with RUFY3 By similarity.

INVOLVEMENT IN DISEASE: Defects in PIK3CA are associated with colorectal cancer (CRC) [MIM:114500].

Defects in PIK3CA are associated with breast cancer [MIM:114480].

Defects in PIK3CA are associated with epithelial ovarian cancer (EOC) [MIM:604370].

Defects in PIK3CA may underlie hepatocellular carcinoma (HCC) [MIM:114550]. Ref.14

PI3KCA mutations affecting exons 9 and 20 display gender- and tissue-specific patterns, thus suggesting that the different amino acid changes could exert distinct functional effects on the oncogenic properties of this enzyme. Furthermore, sexual dimorphisms and tissue specific factors might directly or indirectly influence the occurrence of PI3KCA cancer alleles.

SEQUENCE SIMILARITIES: Belongs to the PI3/PI4-kinase family.

Contains 1 C2 domain.

Contains 1 PI3K/PI4K domain.
Molecular Weight 110 kDa
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Quality Assurance Evaluated by Western Blot on HEK-293 cell lysate.
Western Blot Analysis: 0.05 - 0.1 μg/mL of this antibody detected endogenous PI3 Kinase, p110β in lysate from HEK-293 cells.
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage Conditions Stable for 1 year at 2-8ºC from date of receipt.
Handling Recommendations: Upon receipt, and prior to removing the cap, centrifuge the vial and gently mix the solution.
Packaging Information
Material Size 100 µL
Transport Information
Supplemental Information
Specifications

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