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Rb X GFR Alpha3

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货号：AB5142

品牌：Millipore 密理博

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重要规格表

Species Reactivity Key Applications Host Format Antibody Type
M WB Rb Purified Polyclonal Antibody
Description
Catalogue Number AB5142
Brand Family Chemicon®
Trade Name
  • Chemicon
Description Anti-GFR α3 Antibody
References
Product Information
Format Purified
Presentation Purified
Applications
Application Anti-GFR α3 Antibody is an antibody against GFR α3 for use in WB.
Key Applications
  • Western Blotting
Application Notes Western blot: 1:500 - 1:1000

- Mouse kidney, liver or heart tissue lysates can be used as positive controls

Optimal working dilutions must be determined by end user.
Biological Information
Immunogen Peptide corresponding to the amino acids 347-360 of mouse GFRalpha-3.
Concentration Please refer to the Certificate of Analysis for the lot-specific concentration.
Host Rabbit
Specificity Members of the glial cell line-derived neurotrophic factor (GDNF) family, including GDNF and neurturin (NTN), play key roles in the control of vertebrate neuron survival and differentiation. A new member of the GDNF family was recently identified and designated persephin (Milbrandt et al. 1998). Physiological responses to these neurotrophic factors require two receptor subunits, the novel glycosylphosphadidylinositol linked protein GFRa and Ret receptor tyrosine kinase GFRb (Nomenclature Committee 1997). Following the findings of GFRa-1 and -2, a novel receptor in GFRa family was identified very recently from human and mouse and designated GFRa-3 (Jing et al. 1997; Baloh et al. 1998; Worby et al. 1998; Navelthan et al. 1998; Nomoto et al. 1998). GFRa-3 binds persephin, thus, persephin, GFRa-3 and the Ret PTK form a complex to transduce persephin signal and to mediate persephin function.
Species Reactivity
  • Mouse
Antibody Type Polyclonal Antibody
Entrez Gene Number
Entrez Gene Summary The protein encoded by this gene is a glycosylphosphatidylinositol(GPI)-linked cell surface receptor and a member of the GDNF receptor family. It forms a signaling receptor complex with RET tyrosine kinase receptor and binds the ligand, artemin.
Gene Symbol
  • GFRA3
  • ORFNames=UNQ339/PRO538/PRO3664
  • GFR-alpha-3
  • GFRa-3
UniProt Number
UniProt Summary FUNCTION: SwissProt: O60609 # Receptor for the glial cell line-derived neurotrophic factor, ARTN (artemin). Mediates the artemin-induced autophosphorylation and activation of the RET receptor tyrosine kinase.
SIZE: 400 amino acids; 44511 Da
SUBCELLULAR LOCATION: Cell membrane; Lipid-anchor, GPI-anchor.
TISSUE SPECIFICITY: Widely expressed in adult and fetus which exhibit a similar pattern. Essentially not expressed in the central nervous system, but highly expressed in several sensory and sympathetic ganglia of the peripheral nervous system. Moderate expression in many non-neuronal tissues, particularly those of the digestive and urogenital systems, but high expression in stomach and appendix. Several types of glandular tissues show low expression. Very low or no expression detected in the hematopoietic system.
PTM: N-glycosylated.
SIMILARITY: SwissProt: O60609 ## Belongs to the GDNFR family.
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage Conditions Can be refrigerated at 2-8°C in undiluted aliquots for short-term use, store at -20°C for up to 12 months.
Packaging Information
Material Size 100 µg
Transport Information
Supplemental Information
Specifications

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