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Rb X Semaphorin 3A Affinity Purified

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0.00
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货号：AB9604

品牌：Millipore 密理博

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重要规格表

Species Reactivity Key Applications Host Format Antibody Type
H, R WB Rb Affinity Purified Polyclonal Antibody
Description
Catalogue Number AB9604
Brand Family Chemicon®
Trade Name
  • Chemicon
Description Anti-Semaphorin 3A Antibody, central region
References
Product Information
Format Affinity Purified
Presentation Liquid in PBS containing 50% glycerol, 1 mg/mL BSA and 0.05% sodium azide.
Applications
Application Anti-Semaphorin 3A Antibody, central region detects level of Semaphorin 3A & has been published & validated for use in WB.
Key Applications
  • Western Blotting
Application Notes Western blot: 1:1,000 on neonatal rat brain and recombinant human Semaphorin 3A/Fc chimera (95/125 kDa). The antibody reacts with the ~95 kDa protein. The suggested antibody diluent is PBS containing 5% non-fat milk and 0.04% Tween 20.

Optimal working dilutions must be determined by the end user.
Biological Information
Immunogen Synthetic peptide from the central region of human semaphorin 3A.
Host Rabbit
Specificity Semaphorin 3A. The immunogen sequence has low homology with other semaphorin family members.
Species Reactivity
  • Human
  • Rat
Species Reactivity Note It is expected that the antibody will also react with mouse.
Antibody Type Polyclonal Antibody
Entrez Gene Number
Entrez Gene Summary This gene is a member of the semaphorin family and encodes a protein with an Ig-like C2-type (immunoglobulin-like) domain, a PSI domain and a Sema domain. This secreted protein can function as either a chemorepulsive agent, inhibiting axonal outgrowth, or as a chemoattractive agent, stimulating the growth of apical dendrites. In both cases, the protein is vital for normal neuronal pattern development. Increased expression of this protein is associated with schizophrenia and is seen in a variety of human tumor cell lines. Also, aberrant release of this protein is associated with the progression of Alzheimer's disease.
Gene Symbol
  • SEMA3A
  • SEMAD
  • SEMAIII
  • SEMA1-PEN
  • semaphorin-like
  • MGC133243
  • SEMA1
  • Hsema-I
  • Hsema-III
  • SemD
  • coll-1
  • SEMAL
UniProt Number
UniProt Summary FUNCTION: SwissProt: Q14563 # Induces the collapse and paralysis of neuronal growth cones. Could serve as a ligand that guides specific growth cones by a motility-inhibiting mechanism. Binds to the complex neuropilin-1/plexin-1 (By similarity).
SIZE: 771 amino acids; 88889 Da
SUBCELLULAR LOCATION: Secreted (By similarity).
DOMAIN:SwissProt: Q14563 Strong binding to neuropilin is mediated by the carboxy third of the protein.
SIMILARITY: Belongs to the semaphorin family. & Contains 1 Ig-like C2-type (immunoglobulin-like) domain. & Contains 1 PSI domain. & Contains 1 Sema domain.
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage Conditions Maintain at -20°C in undiluted aliquots for up to 6 months after date of receipt. Avoid repeated freeze/thaw cycles.
Packaging Information
Material Size 100 µL
Transport Information
Supplemental Information
Specifications

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