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Anti-Neurogenin 3 (Rabbit Polyclonal)

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货号：AB5684

品牌：Millipore 密理博

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重要规格表

Species Reactivity Key Applications Host Format Antibody Type
H, M, R IHC Rb Affinity Purified Polyclonal Antibody
Description
Catalogue Number AB5684
Brand Family Chemicon®
Trade Name
  • Chemicon
Description Anti-Neurogenin-3 Antibody, a.a. 80-93 of mouse Neurogenin-3.
Alternate Names
  • MATH4b
Background Information Neurogenins are a family of bHLH transcription factors involved in specifying neuronal differentiation. They are related to Drosophila atonal. The neurogenins (ngns) make up one of these atonal-related gene families. In neural crest cells, the atonal-related neurogenin family is particularly important for the sensory lineage (Neurogenins Are Essential for the Formation of dorsal root ganglia), while the achaete-scute homologue ash1 (Mash1) is important for aspects of autonomic neurogenesis (Mash1 Is Essential for Noradrenergic Differentiation). Neurogenin-3 promotes pancreatic development.
References
Product Information
Format Affinity Purified
Control
  • Rat brain tissue.
Presentation Affinity purified immunoglobulin. Precipitated antibody in a solution of 50% saturated ammonium sulfate and PBS containing no preservatives.
Applications
Application Anti-Neurogenin-3 Antibody, a.a. 80-93 of mouse Neurogenin-3. detects level of Neurogenin-3 & has been published & validated for use in IH.
Key Applications
  • Immunohistochemistry
Application Notes Immunohistochemistry: 1:200-1:1,000.
Immunocytochemistry: Cat. # AB5684 detects Neurogenin-3 in PC12 cells at 1:500 dilution.
Not recommended for Western blot
Biological Information
Immunogen Synthetic peptide, amino acids 80-93 of mouse Neurogenin 3.
Epitope a.a. 80-93 of mouse Neurogenin 3.
Host Rabbit
Specificity Recognizes Neurogenin 3 (MATH4b), a Helix-loop-helix class of transcription factor.
Isotype IgG
Species Reactivity
  • Human
  • Mouse
  • Rat
Antibody Type Polyclonal Antibody
Entrez Gene Number
Entrez Gene Summary Neurogenin-3 (NEUROG3) is expressed in endocrine progenitor cells and is required for endocrine cell development in the pancreas and intestine (Wang et al., 2006 [PubMed 16855267]). It belongs to a family of basic helix-loop-helix transcription factors involved in the determination of neural precursor cells in the neuroectoderm (Gradwohl et al., 2000 [PubMed 10677506]).[supplied by OMIM]
Gene Symbol
  • NEUROG3
  • ATOH5
  • Atoh5
  • ngn3
  • NGN3
  • MATH4B
  • Math4B
  • Neurogenin-3
UniProt Number
UniProt Summary FUNCTION: SwissProt: Q9Y4Z2 # Involved in neurogenesis. Also required for the specification of a common precursor of the 4 pancreatic endocrine cell types (By similarity).
SIZE: 214 amino acids; 22969 Da
SUBUNIT: Efficient DNA binding requires dimerization with another bHLH protein (By similarity).
SUBCELLULAR LOCATION: Nucleus (Potential).
DISEASE: SwissProt: Q9Y4Z2 # Defects in NEUROG3 are the cause of congenital malabsorptive diarrhea 4 (DIAR4) [MIM:610370]. DIAR4 is an autosomal recessive disorder characterized by generalized malabsorption and a paucity of enteroendocrine cells. Patients with congenital diarrhea generally present within the first weeks after birth with severe, life-threatening watery diarrhea that can be classified as either secretory or malabsorptive in nature. Routine clinical evaluation, including intestinal biopsy, may be used to further categorize the diarrhea according to the severity of the inflammation and to assess the integrity of the crypt- villus axis and the architecture of the epithelial layer. On the basis of both clinical and pathological characteristics, various specialized formulas may be used to minimize the diarrheal symptoms, although some children require extended periods of intravenous nutrition to sustain normal growth and development.
SIMILARITY: SwissProt: Q9Y4Z2 ## Contains 1 basic helix-loop-helix (bHLH) domain.
Molecular Weight ~ 23 kDa
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage Conditions Stable for 1 year at -20ºC from date of receipt.
Packaging Information
Material Size 100 µg
Transport Information
Supplemental Information
Specifications

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