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Anti-Human CD49E, FITC Conjugated (Mouse Monoclonal)

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货号：CBL497F

品牌：Millipore 密理博

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Replacement Information

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重要规格表

Species Reactivity Key Applications Host Format Antibody Type
H FC, IF, FUNC M Purified Monoclonal Antibody
Description
Catalogue Number CBL497
Replaces MAB1986
Brand Family Chemicon®
Trade Name
  • Chemicon
Description Anti-CD49e Antibody, clone SAM-1
Alternate Names
  • Integrin alpha5
References
Product Information
Format Purified
Presentation Purified immunoglobulin by ammonium sulphate precipitation followed by ion exchange chromatography. Please see lot specific datasheet for product formulation.
Applications
Application Anti-CD49e Antibody, clone SAM-1 is an antibody against CD49e for use in FC & IF.
Key Applications
  • Flow Cytometry
  • Immunofluorescence
  • Affects Function
Application Notes Functional studies on platelets where VLA-5 acts as a fibronectin receptor. Platelet adhesion to fibronectin is inhibited by CBL 497

Indirect immunofluorescence staining on fresh frozen or acetone or methanol sections, 5-10 micrograms/mL typical.
Immunohistochemistry: Frozen sections (7 µm) of placental tissue fixed with acetone for 1 hr. Antibody used at 1:10 dilution (Sato et al., 2005).
Immunocytochemistry: iolated EVT cells firxed with 0.5% PFA @ 4°C for 15 minutes followed by acetone at -20°C for 2 minutes. Antibody was used at 1:10 dilution (Sato et al., 2005).
FACS: living cell populations or acetone fixed preparations only. Blocking: 10-40 micrograms/mL working concentration (Sato et al., 2005)

Optimal working dilutions must be determined by the end user.
Biological Information
Immunogen U937 cells
Clone SAM-1
Concentration Please refer to the Certificate of Analysis for the lot-specific concentration.
Host Mouse
Specificity The monoclonal antibody is directed against the CD49e antigen (GPIc or VLA-5 alpha chain), which can form distinct complexes with either the CD29 antigen (GP IIa or VLA beta chain), resulting in the VLA-5 (alpha5 beta1) complex which is expressed on human platelets. The monoclonal antibody reacts with platelets and monocytes and also weakly with T cells and granulocytes. It also reacts with various cell types of non-haemopoietic origin.

FUSION PARTNER: SP2/0 myeloma cell line
Isotype IgG2b
Species Reactivity
  • Human
Antibody Type Monoclonal Antibody
Entrez Gene Number
Entrez Gene Summary The product of this gene belongs to the integrin alpha chain family. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This gene encodes the integrin alpha 5 chain. Alpha chain 5 undergoes post-translational cleavage in the extracellular domain to yield disulfide-linked light and heavy chains that join with beta 1 to form a fibronectin receptor. In addition to adhesion, integrins are known to participate in cell-surface mediated signalling.
Gene Symbol
  • ITGA5
  • VLA-5
  • CD49e
  • VLA5A
  • FNRA
UniProt Number
UniProt Summary FUNCTION: SwissProt: P08648 # Integrin alpha-5/beta-1 is a receptor for fibronectin and fibrinogen. It recognizes the sequence R-G-D in its ligands. In case of HIV-1 infection, the interaction with extracellular viral Tat protein seems to enhance angiogenesis in Kaposi's sarcoma lesions.
SIZE: 1049 amino acids; 114536 Da
SUBUNIT: Heterodimer of an alpha and a beta subunit. The alpha subunit is composed of an heavy and a light chain linked by a disulfide bond. Alpha-5 associates with beta-1. Interacts with HPS5. Interacts with HIV-1 Tat.
SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.
SIMILARITY: SwissProt: P08648 ## Belongs to the integrin alpha chain family. & Contains 7 FG-GAP repeats.
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage Conditions Maintain at 2-8°C for up to 12 months from date of receipt.
Packaging Information
Material Size 100 µg
Transport Information
Supplemental Information
Specifications

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