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Anti-Calpain-I (µ-Calpain) (Mouse Monoclonal)

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货号：MAB3104

品牌：Millipore 密理博

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重要规格表

Species Reactivity Key Applications Host Format Antibody Type
H, Ht, M, R ELISA, IP, WB, ICC M Ascites Monoclonal Antibody
Description
Catalogue Number MAB3104
Brand Family Chemicon®
Trade Name
  • Chemicon
Description Anti-Calpain I Antibody, large subunit, clone P9
Alternate Names
  • mu-Calpain
  • μ-Calpain
Background Information Calpains are non-lysosomal cysteine proteeases which absolutely require calcium for activity. There are two major calpain isozymes: μ-calpain and m-calpain, which require micromolar or millimolar calicum for activity, respectively, in invitro assays. The major calpain isozymes are composed of two subunits: an 80kDa catalytic subunit; and a 30kDa regulatory subunit. The large and small subunits remain associated in the presence of calcium after proteolytic activation of the zymogen.
References
Product Information
Format Ascites
Control
  • WI-38 human fibroblasts, or human erthryocytes are suggested as positive controls.
Presentation Liquid
Applications
Application Anti-Calpain I Antibody, large subunit, clone P9 is an antibody against Calpain I for use in ELISA, IP, WB & IC.
Key Applications
  • ELISA
  • Immunoprecipitation
  • Western Blotting
  • Immunocytochemistry
Application Notes Immunoblot: 1:1,000 Detects an 80kDa large subunit μ-calpain, and will also detect the subunit in the non-activated proform of the zymogen, showing a band of ~110kDa. WI-38 human fibroblasts, or human erthryocytes are suggested as positive controls. Immunocytochemistry: 1:100 on A431 epidermal carcinoma.

Immunoprecipitation

ELISA: 1:6,000 (against the immunogen)

Optimal working dilutions must be determined by the end user.
Biological Information
Immunogen Calpain-I large subunit from human erythrocyte calpain.
Epitope large subunit
Clone P9
Host Mouse
Specificity Reacts with human calpain-I (μ-Calpain). P9 does not cross with human placental m-calpain (calpain II). This antibody will immunoprecipitate proteolytically active calpains.
Isotype IgG1
Species Reactivity
  • Human
  • Hamster
  • Mouse
  • Rat
Antibody Type Monoclonal Antibody
Entrez Gene Number
Entrez Gene Summary The calpains, calcium-activated neutral proteases, are nonlysosomal, intracellular cysteine proteases. The mammalian calpains include ubiquitous, stomach-specific, and muscle-specific proteins. The ubiquitous enzymes consist of heterodimers with distinct large, catalytic subunits associated with a common small, regulatory subunit. This gene encodes the large subunit of the ubiquitous enzyme, calpain 1.
Gene Symbol
  • CAPN1
  • CANPL1
  • muCANP
  • CANP
  • muCL
  • Micromolar-calpain
  • EC 3.4.22.52
Non-Reactive Species
  • Canine
UniProt Number
UniProt Summary FUNCTION: SwissProt: P07384 # Calcium-regulated non-lysosomal thiol-protease which catalyze limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction.
COFACTOR: Binds 3 calcium ions.
SIZE: 714 amino acids; 81890 Da
SUBUNIT: Forms a heterodimer with a small (regulatory) subunit (CAPNS1).
SUBCELLULAR LOCATION: Cytoplasm (By similarity). Cell membrane (By similarity). Note=Translocates to the plasma membrane upon Ca(2+) binding (By similarity).
TISSUE SPECIFICITY: Ubiquitous.
SIMILARITY: SwissProt: P07384 ## Belongs to the peptidase C2 family. & Contains 1 calpain catalytic domain. & Contains 4 EF-hand domains.
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage Conditions Maintain at -20°C in undiluted aliquots for up to 12 months. Avoid repeated freeze/thaw cycles.
Packaging Information
Material Size 100 µL
Transport Information
Supplemental Information
Specifications

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