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Qiagen 凯杰 Biosharp Omega

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NA+ /H+ Exchanger Isoform NHE3

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货号：MAB3138

品牌：Millipore 密理博

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Replacement Information

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重要规格表

Species Reactivity Key Applications Host Format Antibody Type
H, M, Mk, R WB, IHC M Purified Monoclonal Antibody
Description
Catalogue Number MAB338
Brand Family Chemicon®
Trade Name
  • Chemicon
Description Anti-Ciliary Neurotrophic Factor Antibody, clone 4-68
Alternate Names
  • CNTF
References
Product Information
Format Purified
Presentation Liquid in 0.02M phosphate buffer, 0.25M NaCl with 0.1% sodium azide, pH 7.6.
Applications
Application This Anti-Ciliary Neurotrophic Factor Antibody, clone 4-68 is validated for use in WB, IH for the detection of Ciliary Neurotrophic Factor.
Key Applications
  • Western Blotting
  • Immunohistochemistry
Application Notes Immunohistochemistry: 10-20 μg/mL on frozen sections of rat sciatic nerve perfused and counter-fixed with 4% paraformaldehyde (Stockli et al., 1991).

Western blotting: 10 μg/mL (Stockli et al., 1991)

Optimal working dilutions must be determined by the end user.
Biological Information
Immunogen Purified ciliary neurotrophic factor from rat sciatic nerve.
Clone 4-68
Concentration Please refer to the Certificate of Analysis for the lot-specific concentration.
Host Mouse
Specificity Ciliary neurotrophic factor. Detects a 22 kD band in Western blots of rat sciatic nerve extract.
Isotype IgG1
Species Reactivity
  • Human
  • Mouse
  • Monkey
  • Rat
Antibody Type Monoclonal Antibody
Entrez Gene Number
Entrez Gene Summary The protein encoded by this gene is a polypeptide hormone whose actions appear to be restricted to the nervous system where it promotes neurotransmitter synthesis and neurite outgrowth in certain neuronal populations. The protein is a potent survival factor for neurons and oligodendrocytes and may be relevant in reducing tissue destruction during inflammatory attacks. A mutation in this gene, which results in aberrant splicing, leads to ciliary neurotrophic factor deficiency, but this phenotype is not causally related to neurologic disease. In addition to the predominant monocistronic transcript originating from this locus, the gene is also co-transcribed with the upstream ZFP91 gene. Co-transcription from the two loci results in a transcript that contains a complete coding region for the zinc finger protein but lacks a complete coding region for ciliary neurotrophic factor.
Gene Symbol
  • CNTF
  • HCNTF
UniProt Number
UniProt Summary FUNCTION: SwissProt: P26441 # CNTF is a survival factor for various neuronal cell types. Seems to prevent the degeneration of motor axons after axotomy.
SIZE: 200 amino acids; 22931 Da
SUBUNIT: Homodimer.
SUBCELLULAR LOCATION: Cytoplasm.
TISSUE SPECIFICITY: Nervous system.
SIMILARITY: SwissProt: P26441 ## Belongs to the CNTF family.
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage Conditions Maintain at 2-8°C for up to 6 months. Avoid repeated freeze/thaw cycles.
Packaging Information
Material Size 100 µg
Transport Information
Supplemental Information
Specifications

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