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Ms X Kinesin Light Chain

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货号：MAB1617

品牌：Millipore 密理博

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重要规格表

Species Reactivity Key Applications Host Format Antibody Type
Ma ELISA, IP, RIA, WB M Purified Monoclonal Antibody
Description
Catalogue Number MAB1617
Brand Family Chemicon®
Trade Name
  • Chemicon
Description Anti-Kinesin Antibody, light chain, clone L2
References
Product Information
Format Purified
Presentation Liquid in 0.02 M Phosphate buffer, 0.25 M NaCl with 0.1% sodium azide.
Applications
Application Anti-Kinesin Antibody, light chain, clone L2 is an antibody against Kinesin for use in ELISA, IP, RIA & WB.
Key Applications
  • ELISA
  • Immunoprecipitation
  • Radioimmunoassay
  • Western Blotting
Application Notes Immunoblotting

Immunoprecipitation

EIA/RIA

Optimal working dilutions must be determined by the end user.

Note: Does not work for immunohistochemistry and works only marginally for immunocytochemistry.
Biological Information
Immunogen Bovine brain kinesin.
Epitope light chain
Clone L2
Concentration Please refer to the Certificate of Analysis for the lot-specific concentration.
Host Mouse
Specificity Reacts with the light chain of kinesin near the C-terminal.
Isotype IgG2a
Species Reactivity
  • Mammals
Antibody Type Monoclonal Antibody
Entrez Gene Number
Entrez Gene Summary Conventional kinesin is a tetrameric molecule composed of two heavy chains and two light chains, and transports various cargos along microtubules toward their plus ends. The heavy chains provide the motor activity, while the light chains bind to various cargos. This gene encodes a member of the kinesin light chain family. It associates with kinesin heavy chain through an N-terminal domain, and six tetratricopeptide repeat (TPR) motifs are thought to be involved in binding of cargos such as vesicles, mitochondria, and the Golgi complex. Thus, kinesin light chains function as adapter molecules and not motors per se. Although previously named "kinesin 2", this gene is not a member of the kinesin-2 / kinesin heavy chain subfamily of kinesin motor proteins. Extensive alternative splicing produces isoforms with different C-termini that are proposed to bind to different cargos; however, the full-length nature of some of these variants has not been determined.
Gene Symbol
  • KLC1
  • hKLC1R
  • KNS2
  • KLC
  • KNS2A
  • hKLC1S
  • hKLC1P
  • hKLC1N
  • MGC15245
  • hKLC1J
  • hKLC1G
  • hKLC1B
UniProt Number
UniProt Summary FUNCTION: SwissProt: Q07866 # Kinesin is a microtubule-associated force-producing protein that may play a role in organelle transport. The light chain may function in coupling of cargo to the heavy chain or in the modulation of its ATPase activity.
SIZE: 569 amino acids; 64786 Da
SUBUNIT: Oligomeric complex composed of two heavy chains and two light chains. Interacts with SPAG9 (By similarity).
TISSUE SPECIFICITY: Found in a variety of tissues. Mostly abundant in brain and spine.
PTM: Isoform I is phosphorylated on Ser-596.
SIMILARITY: SwissProt: Q07866 ## Belongs to the kinesin light chain family. & Contains 6 TPR repeats.
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage Conditions Maintain at 2-8°C in undiluted aliquots for up to 6 months.
Packaging Information
Material Size 100 µg
Transport Information
Supplemental Information
Specifications

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