Mouse Anti-Slow Muscle Myosin Monoclonal Antibody

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Mouse Anti-Slow Muscle Myosin Monoclonal Antibody

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货号：MAB1628

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重要规格表

Species Reactivity	Key Applications	Host	Format	Antibody Type
H, R, Fe	RIA, WB, IHC	M	Purified	Monoclonal Antibody

Description
Catalogue Number	MAB1628
Brand Family	Chemicon®
Trade Name	Chemicon
Description	Anti-Myosin Antibody, slow muscle, clone NOQ7.5.4D

References

Product Information
Format	Purified
Presentation	Liquid.

Applications
Application	Anti-Myosin Antibody, slow muscle, clone NOQ7.5.4D is an antibody against Myosin for use in RIA, WB, IH.
Key Applications	Radioimmunoassay Western Blotting Immunohistochemistry
Application Notes	Immunohistochemistry: frozen and formalin fixed sections. Immunoblotting RIA Optimal working dilutions must be determined by end user.

Biological Information
Immunogen	Myosin purified from myofibrils isolated from histochemically mixed human skeletal muscle.
Epitope	slow muscle
Clone	NOQ7.5.4D
Concentration	Please refer to the Certificate of Analysis for the lot-specific concentration.
Host	Mouse
Specificity	Slow myosin heavy chain. Clearly identifies Type 1 fibers. Within skeletal muscle MAB1628 is specific for slow myosin heavy chain in a wide variety of species. It reacts strongly with rat and feline slow myosin heavy chain. MAB1628 also identifies beta (slow) myosin heavy chain in heart ventricles.
Isotype	IgG
Species Reactivity	Human Rat Feline
Antibody Type	Monoclonal Antibody
Entrez Gene Number	NM_000257.2
Entrez Gene Summary	MYH7 encodes the cardiac muscle beta (or slow) isoform of myosin. Changes in the relative abundance of MYH7 and MYH6 (the alpha, or fast, isoform of cardiac myosin heavy chain) correlate with the contractile velocity of cardiac muscle. Mutations in MYH7 are associated with familial hypertrophic cardiomyopathy.
Gene Symbol	MYH7 Myosin-7 MYHCB MyHC-beta CMD1S MGC138378 MPD1 DKFZp451F047 MGC138376 CMH1
UniProt Number	P12883
UniProt Summary	FUNCTION: SwissProt: P12883 # Muscle contraction. SIZE: 1935 amino acids; 223097 Da SUBUNIT: Muscle myosin is a hexameric protein that consists of 2 heavy chain subunits (MHC), 2 alkali light chain subunits (MLC) and 2 regulatory light chain subunits (MLC-2). SUBCELLULAR LOCATION: Cytoplasm, myofibril. Note=Thick filaments of the myofibrils. DOMAIN: SwissProt: P12883 The rodlike tail sequence is highly repetitive, showing cycles of a 28-residue repeat pattern composed of 4 heptapeptides, characteristic for alpha-helical coiled coils. DISEASE: SwissProt: P12883 # Defects in MYH7 are the cause of familial hypertrophic cardiomyopathy type 1 (CMH1) [MIM:192600]; also designated FHC or HCM. Hypertrophic cardiomyopathy is a heart disorder characterized by ventricular hypertrophy, which is usually asymmetric and often involves the interventricular septum. The prevalence of the disease in the general population is 0.2%. FHC is clinically heterogeneous, with inter- and intrafamilial variations ranging from benign to malignant forms with high risk of cardiac failure and sudden cardiac death. & Defects in MYH7 are the cause of myosin storage myopathy [MIM:608358]. In this disorder, muscle biopsy shows type 1 fiber predominance and increased interstitial fat and connective tissue. Inclusion bodies consisting of the beta cardiac myosin heavy chain are present in the majority of type 1 fibers, but not in type 2 fibers. & Defects in MYH7 are a cause of dilated cardiomyopathy (CMD) [MIM:115200]. CMD is a disorder characterized by cardiac dilation and reduced systolic function. & Defects in MYH7 are the cause of Laing early-onset distal myopathy (MPD1) [MIM:160500]. MPD1 is an autosomal dominant disorder which differs from other distal myopathies in that onset is as early as 4 years of age. Selective weakness of the anterior tibial muscles is followed by weakness of the finger extensors and selected proximal muscle groups such as the hip abductors and rotators, the shoulder abductors and the sternocleidomastoids. SIMILARITY: Contains 1 IQ domain. & Contains 1 myosin head-like domain. MISCELLANEOUS: Each myosin heavy chain can be split into 1 light meromyosin (LMM) and 1 heavy meromyosin (HMM). It can later be split further into 2 globular subfragments (S1) and 1 rod-shaped subfragment (S2). & The cardiac alpha isoform is a 'fast' ATPase myosin, while the beta isoform is a 'slow' ATPase.

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Product Usage Statements
Usage Statement	Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Conditions	Maintain at 2-8°C.

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Material Size	100 µg

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Mouse Anti-Slow Muscle Myosin Monoclonal Antibody

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