LAMININ-SPECIFIC INTEGRINS KIT

Description
Catalogue Number	ECM420
Brand Family	Chemicon®
Trade Name	Chemicon
Description	Laminin-Specific Integrins Investigator Kit
Overview	Chemicon Investigator Kits for Integrin Research are a cost-effective source of reagents for all investigators intimately involved with this expanding field of study. The kit is designed for research focusing on integrins which are known to interact with Laminin. These include alpha1, alpha2, alpha3, alpha6, and alpha7 (not included with kit) which combine with the integrin beta1 subunit. The alpha6 subunit is also known to combine with the beta4 subunit. [Hynes, R. 1992. Cell 69:11-25] Integrins belong to a large family of cell surface proteins commonly referred to as glycoproteins. Integrins are composed of noncovalently associated alpha and beta subunits which make up heterodimers: the larger termed alpha chain and the smaller beta chain. At least 16 alpha subunits and 8 beta subunits are expressed, which can give rise to 22 different integrins. Integrins are thought to play critical roles in cell migration, differentiation, and survival. There is now considerable evidence that these transmembrane receptors play an important role in the regulation of gene expression and signal transduction. Excellent reviews of integrin structure, function, and ligand specificity may be found in: Hynes, R. 1992. Cell 69:11-25; Kramer, R. 1993. "Integrin Structure and Ligand Specificity in Cell-Matrix Interactions" in Molecular and Cellular Aspects of Basement Membranes. Academic Press. Chemicon offers the Laminin-Specific Integrins Investigator Kit for initial studies of Integrin/Laminin interactions. All kit reagents are also available in larger sizes. The reagents in this kit are not application specific but rather may be used in a variety of procedures, depending upon the needs of the individual investigator.

Description

Catalogue Number

ECM420

Brand Family

Chemicon®

Trade Name

Chemicon

Description

Laminin-Specific Integrins Investigator Kit

Overview

Chemicon Investigator Kits for Integrin Research are a cost-effective source of reagents for all investigators intimately involved with this expanding field of study. The kit is designed for research focusing on integrins which are known to interact with Laminin. These include alpha1, alpha2, alpha3, alpha6, and alpha7 (not included with kit) which combine with the integrin beta1 subunit. The alpha6 subunit is also known to combine with the beta4 subunit. [Hynes, R. 1992. Cell 69:11-25]

Integrins belong to a large family of cell surface proteins commonly referred to as glycoproteins. Integrins are composed of noncovalently associated alpha and beta subunits which make up heterodimers: the larger termed alpha chain and the smaller beta chain. At least 16 alpha subunits and 8 beta subunits are expressed, which can give rise to 22 different integrins. Integrins are thought to play critical roles in cell migration, differentiation, and survival. There is now considerable evidence that these transmembrane receptors play an important role in the regulation of gene expression and signal transduction. Excellent reviews of integrin structure, function, and ligand specificity may be found in: Hynes, R. 1992. Cell 69:11-25; Kramer, R. 1993. "Integrin Structure and Ligand Specificity in Cell-Matrix Interactions" in Molecular and Cellular Aspects of Basement Membranes. Academic Press.

Chemicon offers the Laminin-Specific Integrins Investigator Kit for initial studies of Integrin/Laminin interactions. All kit reagents are also available in larger sizes. The reagents in this kit are not application specific but rather may be used in a variety of procedures, depending upon the needs of the individual investigator.

Product Information
Components	alpha1 Mouse Monoclonal Antibody (Part No. MAB1973Z-20) - 1 tube, 20 μg. alpha2 Mouse Monoclonal Antibody (Part No. MAB1950Z-20)- 1 tube, 20 μg. alpha3 Mouse Monoclonal Antibody (Part No. MAB2056-20) - 1 tube, 20 μg. alpha6 Rat Monoclonal Antibody (Part No. MAB1378-20)- 1 tube, 20 μg. beta1 Mouse Monoclonal Antibody (Part No. MAB1951Z-20) - 1 tube, 20 μg. beta4 Mouse Monoclonal Antibody (Part No. MAB2058-20) - 1 tube, 20 μg.
Presentation	Chemicon's Laminin Specific Integrins Kit (ECM420) is useful for the study of Laminin-associated integrins. Chemicon's ECM420 kit provides 20 μg each of monoclonals to alpha1, alpha2, alpha3, alpha6, beta1, and beta4.

Product Information

Components

alpha1 Mouse Monoclonal Antibody (Part No. MAB1973Z-20) - 1 tube, 20 μg.
alpha2 Mouse Monoclonal Antibody (Part No. MAB1950Z-20)- 1 tube, 20 μg.
alpha3 Mouse Monoclonal Antibody (Part No. MAB2056-20) - 1 tube, 20 μg.
alpha6 Rat Monoclonal Antibody (Part No. MAB1378-20)- 1 tube, 20 μg.
beta1 Mouse Monoclonal Antibody (Part No. MAB1951Z-20) - 1 tube, 20 μg.
beta4 Mouse Monoclonal Antibody (Part No. MAB2058-20) - 1 tube, 20 μg.

Presentation

Chemicon's Laminin Specific Integrins Kit (ECM420) is useful for the study of Laminin-associated integrins. Chemicon's ECM420 kit provides 20 μg each of monoclonals to alpha1, alpha2, alpha3, alpha6, beta1, and beta4.

Applications
Key Applications	ELISA

Applications

Key Applications

ELISA

Biological Information
Species Reactivity	Human

Biological Information

Species Reactivity

Human

Product Usage Statements
Usage Statement	Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Product Usage Statements

Usage Statement

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Storage and Shipping Information
Storage Conditions	Store antibodies at -20°C. Important Note: Due to the small volumes contained within the kit, we recommend gently tapping the vial on a hard surface or briefly centrifuging the vial in a tabletop centrifuge before opening to dislodge any liquid entrapped in the container's cap during shipment.

Storage and Shipping Information

Storage Conditions

Store antibodies at -20°C.

Important Note: Due to the small volumes contained within the kit, we recommend gently tapping the vial on a hard surface or briefly centrifuging the vial in a tabletop centrifuge before opening to dislodge any liquid entrapped in the container's cap during shipment.

Packaging Information
Material Size	1 kit

Packaging Information

Material Size

1 kit

实验耗材

分子生物学试剂

蛋白与免疫学

生化试剂

细胞及检测试剂

色谱及层析

仪器设备

实验服务

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LAMININ-SPECIFIC INTEGRINS KIT

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