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Ms X Hu Collagen Type V

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货号：MAB3302

品牌：Millipore 密理博

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重要规格表

Species Reactivity Key Applications Host Format Antibody Type
H, M, R, Sh ELISA, IHC, IH(P), WB M Purified Monoclonal Antibody
Description
Catalogue Number MAB302
Brand Family Chemicon®
Trade Name
  • Chemicon
Description Anti-Glutamine Synthetase Antibody, clone GS-6
Background Information Glutamine Synthetase catalyzes the conversion of ammonia and glutamate to glutamine. It is found in astrocytes as an octamer of identical 45 kDa subunits. The function of Glutamine Synthetase is the detoxification of brain ammonia. It also has an important role in the metabolic regulation of neurotransmitter glutamate. Because of the multiple functions and importance of Glutamine Synthetase in cellular metabolism, both catalytic activities and synthesis are highly regulated. The activity of Glutamine Synthetase is controlled by adenylylation. Its activity is decreased in the cerebral cortex of brains affected by Alzheimer's disease, particularly in the vicinity of senile plaques. It is also decreased under conditions of glucose deprivation. The level of expression of Glutamine Synthetase is increased during ischemia in vivo or hypoxia in culture.
References
Product Information
Format Purified
Control
  • Rat brain tissue, rat brain cytosolic fraction extract
Presentation Purified immunoglobulin. Liquid in buffer containing 50% glycerol, BSA and 0.09% sodium azide.
Applications
Application Detect Glutamine Synthetase using this Anti-Glutamine Synthetase Antibody, clone GS-6 validated for use in ELISA, IH, IH(P) & WB with more than 45 product citations.
Key Applications
  • ELISA
  • Immunohistochemistry
  • Immunohistochemistry (Paraffin)
  • Western Blotting
Application Notes Western blot: 1:1,000-1:5,000

Immunohistochemistry on rat brain

ELISA

Optimal working dilutions must be determined by end user.
Biological Information
Immunogen Glutamine synthetase purified from sheep brain.
Clone GS-6
Concentration Please refer to the Certificate of Analysis for the lot-specific concentration.
Host Mouse
Specificity Reacts strongly with a single band on Western blots of sheep brain and rat brain. Glutamine synthetase, an enzyme that catalyzes the amination of glutamic acid to form glutamine, is found in mammals as an octamer of eight identical 45 kDa subunits. Glutamine synthetase activity has been shown to be a useful marker of astrocytes and an important differentiation feature in retina. Glutamine synthetase is also considered to be a key enzyme in the recycling of the neurotransmitter glutamate.
Isotype IgG2a
Species Reactivity
  • Human
  • Mouse
  • Rat
  • Sheep
Antibody Type Monoclonal Antibody
Entrez Gene Number
Entrez Gene Summary Glutamine is a main source of energy and is involved in cell proliferation, inhibition of apoptosis, and cell signaling (Haberle et al., 2005 [PubMed 16267323]). Fetal glutamine requirements are very high and depend largely on active glutamine synthesis and the release of glutamine into the fetal circulation by the placenta. Glutamine synthetase (EC 6.3.1.2), also called glutamate-ammonia ligase (GLUL), is expressed throughout the body and plays an important role in controlling body pH and in removing ammonia from the circulation. The enzyme clears L-glutamate, the major neurotransmitter in the central nervous system, from neuronal synapses (see references in Clancy et al., 1996 [PubMed 8975719]).[supplied by OMIM]
Gene Symbol
  • GLUL
  • GLNS
Purification Method Protein A Purfied
UniProt Number
UniProt Summary FUNCTION: SwissProt: P15104 # Catalyzes the conversion of ammonia and L-glutamate to L-glutamine.
SIZE: 373 amino acids; 42064 Da
SUBUNIT: Homooctamer.
SUBCELLULAR LOCATION: Cytoplasm.
DISEASE:SwissProt: P15104 # Defects in GLUL are the cause of congenital systemic glutamine deficiency (CSGD) [MIM:610015]. CSGD is a rare developmental disorder with severe brain malformation resulting in multi-organ failure and neonatal death. Glutamine is largely absent from affected patients serum, urine and cerebrospinal fluid.
SIMILARITY: SwissProt: P15104 ## Belongs to the glutamine synthetase family.
Molecular Weight 45 kDa
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage Conditions Stable for 1 year at -20ºC in undiluted aliquots from date of receipt.
Packaging Information
Material Size 100 µg
Transport Information
Supplemental Information
Specifications

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