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Qiagen 凯杰 Biosharp Omega

首页细胞生物学检测Millipore 密理博>

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HUMAN ADAM10 CONTROL PEPTIDE FOR AB19026

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货号：AG533

品牌：Millipore 密理博

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Replacement Information
Description
Catalogue Number AG533
Brand Family Chemicon®
Trade Name
  • Chemicon
Description ADAM 10, control peptide for AB19026
Overview Control peptide for Chemicon Cat. No. AB19026 (Rabbit anti-ADAM10). Peptide corresponds to amino acids 732-748 near the C-terminus.
References
Product Information
Presentation Liquid in PBS, pH 7.2, containing 0.1% BSA and 0.02% sodium azide.
Applications
Key Applications
  • Peptide Inhibition Assay
Application Notes Blocking: Use 1 μg control peptide per 1 μg antibody . Control peptide, because of it's small size (2-3 kDa), is not recommended for Western.

Optimal working dilutions must be determined by end user.
Biological Information
Concentration 0.2 mg/mL
Source Synthetic peptide
Entrez Gene Number
Entrez Gene Summary Members of the ADAM family are cell surface proteins with a unique structure possessing both potential adhesion and protease domains. This gene encodes and ADAM family member that cleaves many proteins including TNF-alpha and E-cadherin.
Gene Symbol
  • ADAM10
  • CDw156
  • CD156c
  • HsT18717
  • kuzbanian
  • kuz
  • MADM
  • KUZ
  • EC 3.4.24.81
UniProt Number
UniProt Summary FUNCTION: SwissProt: O14672 # Cleaves the membrane-bound precursor of TNF-alpha at '76-Ala- -Val-77' to its mature soluble form. Responsible for the proteolytic release of several other cell-surface proteins, including heparin-binding epidermal growth-like factor, ephrin-A2 and for constitutive and regulated alpha-secretase cleavage of amyloid precursor protein (APP). Contributes to the normal cleavage of the cellular prion protein. Involved in the cleavage of the adhesion molecule L1 at the cell surface and in released membrane vesicles, suggesting a vesicle-based protease activity. Controls also the proteolytic processing of Notch and mediates lateral inhibition during neurogenesis (By similarity).
COFACTOR: Binds 1 zinc ion (By similarity).
SIZE: 748 amino acids; 84142 Da
SUBUNIT: Interacts with ephrin-A2 (By similarity).
SUBCELLULAR LOCATION: Cell membrane; Single-pass type I membrane protein. Intracytoplasmic membrane; Single-pass type I membrane protein. Note=Is localized in the plasma membrane but is predominantly expressed in the Golgi apparatus and in released membrane vesicles derived likely from the Golgi.
TISSUE SPECIFICITY: Expressed in spleen, lymph node, thymus, peripheral blood leukocyte, bone marrow, cartilage, chondrocytes and fetal liver.
DOMAIN: SwissProt: O14672 The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme.
PTM: The precursor is cleaved by a furin endopeptidase (By similarity).
SIMILARITY: Contains 1 disintegrin domain. & Contains 1 peptidase M12B domain.
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage Conditions Maintain at -20°C for up to 12 months from date of receipt. Avoid repeated freeze/thaw cycles.
Packaging Information
Material Size 50 µg
Transport Information
Supplemental Information
Specifications

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