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Ms X GFAP Alexa Fluor® 488 Conjugated (Mouse Monoclonal)

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货号：MAB3402X

品牌：Millipore 密理博

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重要规格表

Species Reactivity Key Applications Host Format Antibody Type
Ch, H, Po, R ICC, IHC M AlexaFluor®488 Monoclonal Antibody
Description
Catalogue Number MAB3402X
Brand Family Chemicon®
Trade Name
  • Chemicon
Description Anti-Glial Fibrillary Acidic Protein Antibody, clone GA5, Alexa Fluor® 488
Alternate Names
  • GFAP
References
Product Information
Format AlexaFluor®488
Presentation Purified immunoglobulin conjugated to Alexa Fluor® 488. Liquid in Phosphate buffer with 15 mg/mL BSA as a stabilizer and 0.1% sodium azide.
Applications
Application Detect Glial Fibrillary Acidic Protein using this Anti-Glial Fibrillary Acidic Protein Antibody, clone GA5, Alexa Fluor 488 validated for use in IC, IH.
Key Applications
  • Immunocytochemistry
  • Immunohistochemistry
Application Notes Immunocytochemistry

Immunohistochemistry

Optimal working dilutions must be determined by end user.
Biological Information
Immunogen Purified glial filament (1).
Clone clone GA5
Concentration Please refer to the Certificate of Analysis for the lot-specific concentration.
Host Mouse
Specificity The antibody reacts with GFAP from human, pig, chicken and rat. In tissue sections this antibody stains astrocytes and Bergman glia cells (1).
Isotype IgG1
Species Reactivity
  • Chicken
  • Human
  • Pig
  • Rat
Antibody Type Monoclonal Antibody
Entrez Gene Number
Entrez Gene Summary This gene encodes one of the major intermediate filament proteins of mature astrocytes. It is used as a marker to distinguish astrocytes from other glial cells during development. Mutations in this gene cause Alexander disease, a rare disorder of astrocytes in the central nervous system. An additional transcript variant has been described, but its full length sequence has not been determined.
Gene Symbol
  • GFAP
  • FLJ45472
UniProt Number
UniProt Summary FUNCTION: SwissProt: P14136 # GFAP, a class-III intermediate filament, is a cell- specific marker that, during the development of the central nervous system, distinguishes astrocytes from other glial cells.
SIZE: 432 amino acids; 49880 Da
SUBUNIT: Isoform 3 interacts with N-terminus of PSEN1.
SUBCELLULAR LOCATION: Cytoplasm. Note=Associated with intermediate filaments.
DISEASE: SwissProt: P14136 # Defects in GFAP are a cause of Alexander disease [MIM:203450]. Alexander disease is a rare disorder of the central nervous system. It is a progressive leukoencephalopathy whose hallmark is the widespread accumulation of Rosenthal fibers which are cytoplasmic inclusions in astrocytes. The most common form affects infants and young children, and is characterized by progressive failure of central myelination, usually leading to death usually within the first decade. Infants with Alexander disease develop a leukoencephalopathy with macrocephaly, seizures, and psychomotor retardation. Patients with juvenile or adult forms typically experience ataxia, bulbar signs and spasticity, and a more slowly progressive course.
SIMILARITY: SwissProt: P14136 ## Belongs to the intermediate filament family.
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Usage Statement
  • Alexa Fluor® is a registered trademark of Molecular Probes, Inc.
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage Conditions Maintain at 2-8°C in the dark for up to 6 months after date of receipt.
Packaging Information
Material Size 100 µg
Transport Information
Supplemental Information
Specifications

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