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VGLUT1 Control Peptide

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货号：AG208

品牌：Millipore 密理博

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Description
Catalogue Number AG208
Brand Family Chemicon®
Trade Name
  • Chemicon
Description Vesicular Glutamate Transporter 1, control peptide for AB5905
Overview Synthetic peptide from rat VGLUT1 protein.
Alternate Names
  • VGLUT1
  • BNPI
Background Information VGLUT1 is expressed in a subset of glutamate neurons and transports glutamate into native synaptic vesicles from the brain, exhibiting a conductance for chloride that is blocked by glutamate. Vesicular glutamate transport has a substantially lower apparent affinity than the plasma membrane excitatory amino acid transporters. Glutamate transport by VGLUT1 is saturated with a K(m) of approximately 2 mM, in the same range as transport by synaptic vesicles. Finally, plasma membrane glutamate transporters recognize both aspartate and glutamate as substrates, whereas VGLUT1 does not recognize aspartate.
References
Product Information
Presentation Liquid.
Applications
Key Applications
  • Cell Function Assay
Application Notes For use in blocking the reactivity of AB5905.

Optimal working dilution must be determined by the end user.
Biological Information
Concentration 1 mg/mL
Entrez Gene Number
Entrez Gene Summary a Na(+)-dependent inorganic phosphate cotransporter.
Gene Symbol
  • VGluT1
  • Solute carrier family 17 member 7
  • Brain-specific Na(+)-dependent inorganic phosphate cotransporter
  • Slc17a7
  • Bnpi
UniProt Number
UniProt Summary FUNCTION: SwissProt: Mediates the uptake of glutamate into synaptic vesicles at presynaptic nerve terminals of excitatory neural cells. May also mediate the transport of inorganic phosphate.
SIZE: 560 amino acids; 61665 Da [MW of unprocessed precursor]
SUBCELLULAR LOCATION: Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane. Membrane; Multi-pass membrane protein (Potential). Cell junction, synapse, synaptosome.
TISSUE SPECIFICITY: Expressed in the cerebellum, cerberal cortex and hippocampus. Isoform 2 is expressed specifically in retina.
SIMILARITY: Belongs to the major facilitator superfamily. Sodium/anion cotransporter family. VGLUT subfamily.
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage Conditions Maintain at -20°C in undiluted aliquots for up to 3 months after date of receipt. Avoid repeated freeze/thaw cycles.
Packaging Information
Material Size 100 µg
Transport Information
Supplemental Information
Specifications

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