Anti-CD34 Class I, cln B1-3C5, (mouse monoclonal) - 炼石商城

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Anti-CD34 Class I, cln B1-3C5, (mouse monoclonal)

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货号：MAB4211

品牌：Millipore 密理博

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北京朝阳

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EA (预计3-5工作日到货)

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重要规格表

Species Reactivity	Key Applications	Host	Format	Antibody Type
H	FC, IF	M	Purified	Monoclonal Antibody

Description
Catalogue Number	MAB4211
Brand Family	Chemicon®
Trade Name	Chemicon
Description	Anti-CD34 Class I Antibody, clone B1-3C5

References

Product Information
Format	Purified
Presentation	The antibody is supplied in phosphate buffered saline, pH 7.4, containing 0.2% bovine serum albumin and 0.1% sodium azide. The characteristics of each lot are tested by electrophoresis and flow cytometry.

Applications
Application	Detect CD34 Class I using this Anti-CD34 Antibody (Class 1), clone B1-3C5 validated for use in FC & IF.
Key Applications	Flow Cytometry Immunofluorescence
Application Notes	Identification of CD34 positive cells is important for the diagnosis and classification of acute myeloid leukemia (AML). It is especially useful in patients with poorly differentiated myeloblasts, as well as in myeloblastic crises of chronic granulocytic leukemia. It has been recommended that this antibody be used as part of a panel for screening of leukemia (Batinic et al., 1989). SUGGESTED USAGE DILUTION 1. Flow cytometry and indirect immunofluorescence 1:25 Dilute with isotonic buffer. Use 50 μl of diluted antibody per 1 x 10E6 peripheral blood mononuclear cells (PBMC) or bone marrow cells in 100 μl of buffer. 2. Indirect immunoperoxidase staining - the final dilution will depend on the assay conditions and detection system employed. However, a dilution of at least 1:25 will be applicable to most commonly used systems.

Biological Information
Immunogen	KG1 human acute myelogenous cell line.
Clone	B1-3C5
Host	Mouse
Specificity	This antibody belongs to CD34 (assigned by the Third International Workshop on Leukocyte Differentiation Antigens, Oxford, 1987; Hogg & Horton, 1987). It reacts with a 120kD glycoprotein found on progenitor cell populations in human bone marrow and foetal liver (Katz et al., 1985). This antigen is normally restricted to immature human haemopoietic precursor cells (Peschel & Koller, 1989). Cell reactivity (Tindle et al., 1985): Normal: No reaction with normal peripheral lymphocytes, granulocytes, monocytes, erythrocytes and platelets. Reacts with <4% of cells in normal bone marrow. Clinical: Reaction Acute myeloid leukemia (AML, M1 and M2) positive Null lymphoblastic leukemia (Null ALL) positive Common acute lymphoblastic leukemia (CALL) positive Myeloblastic and lymphoblastic crises of chronic granulocytic leukemia (CGL) positive Chronic myeloid leukemia (CML) negative T cell acute lymphoblastic leukemia (TALL) negative B cell acute lymphoblastic leukemia (BALL) negative Chronic lymphocytic leukemia (CLL) negative Cell lines: Reacts with early myeloblast line KG1. No reaction with null, B or T lymphoid, erythroid or later myeloid cell lines.
Isotype	IgG1
Species Reactivity	Human
Antibody Type	Monoclonal Antibody
Entrez Gene Number	NM_001025109.1 NM_001773.2
Entrez Gene Summary	CD34 is a monomeric cell surface antigen with a molecular mass of approximately 110 kD that is selectively expressed on human hematopoietic progenitor cells.[supplied by OMIM]
Gene Symbol	CD34
UniProt Number	P28906
UniProt Summary	FUNCTION: SwissProt: P28906 # Possible adhesion molecule with a role in early hematopoiesis by mediating the attachment of stem cells to the bone marrow extracellular matrix or directly to stromal cells. Could act as a scaffold for the attachment of lineage specific glycans, allowing stem cells to bind to lectins expressed by stromal cells or other marrow components. Presents carbohydrate ligands to selectins. SIZE: 385 amino acids; 40716 Da SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein. TISSUE SPECIFICITY: Selectively expressed on hematopoietic progenitor cells and the small vessel endothelium of a variety of tissues. DEVELOPMENTAL STAGE: On early hematopoietic progenitor cells. PTM: Highly glycosylated. & Phosphorylated on serine residues by PKC. DISEASE:SwissProt: P28906 # Abnormal CD34 expression in leukemogenesis. SIMILARITY: SwissProt: P28906 ## Belongs to the CD34 family.

Physicochemical Information

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Materials Information

Toxicological Information

Safety Information according to GHS

Safety Information

Product Usage Statements
Availability by Geography	This product is not available for sale in the United States.
Usage Statement	Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Storage and Shipping Information
Storage Conditions	For prolonged periods, store below -20°C in undiluted aliquots. AVOID REPEATED FREEZE/THAW CYCLES. Product stable for 6 months when stored as directed. WARNING: The monoclonal reagent solution contains 0.1% sodium azide as a preservative. Due to potential hazards arising from the build up of this material in pipes, spent reagent should be disposed of with liberal volumes of water.

Packaging Information
Material Size	100 µg

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