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Anti-alpha Internexin (mouse monoclonal)

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货号：MAB5224

品牌：Millipore 密理博

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重要规格表

Species Reactivity Key Applications Host Format Antibody Type
H, Ma ELISA, IP, WB, IH(P) M Culture Supernatant Monoclonal Antibody
Description
Catalogue Number MAB5224
Replaces 04-1032
Brand Family Chemicon®
Trade Name
  • Chemicon
Description Anti-Internexin α Antibody, CT, clone 2E3
Background Information The protein alpha-internexin is a ~66 kDa Class IV intermediate filament originally discovered as it copurifies with other neurofilament subunits {Pachter J et al J. Cell Biol 101:1316-22 (1985). It is related to but distinct from the better known neurofilament triplet proteins, NF-L, NF-M and NF-H, having similar protein sequence motifs and a similar intron organization. It is expressed in large amounts early in neuronal development, but is downregulated in many neurons as development procedes. Many classes of mature neurons contain alpha-internexin in addition to NF-L, NF-M anbd NF-H. In some mature neurons alpha-internexin is the only neurofilament subunit expressed. Antibodies to a-internexin are therefore unique probes to study and classify neuronal types and follow their processes in sections and in tissue culture. In addition the very early developmental expression of alpha-internexin means its presence is an early and convenient diagnostic feature of neuronal progenitors cells and other cell committed to the neuronal lineage. In addition recent studies show a marked up-regulation of a-internexin during neuronal regeneration {McGraw et al 2002}. The use of antibodies to this protein in the study of brain tumors has not been examined to date, but is likely to be of interest.
References
Product Information
Format Culture Supernatant
Presentation Mouse IgG in low serum (1%), tissue culture supernatant containing no preservative.
Applications
Application This Anti-Internexin Antibody, α, C-terminus, clone 2E3 is validated for use in ELISA, IP, WB, IH(P) for the detection of Internexin.
Key Applications
  • ELISA
  • Immunoprecipitation
  • Western Blotting
  • Immunohistochemistry (Paraffin)
Application Notes Western blot: antibody detects a protein band at 55-66kDa, as expected for alpha internexin {Evans, et al, 2001}.

Immunocytochemistry on PC12 and Ntera-2 cells.

Immunohistochemistry on formalin and methanol fixed tissues. Works on paraffin embedded tissue sections.

Immunoprecipitation

ELISA

Optimal working dilutions must be determined by the end user.
Biological Information
Immunogen Full length recombinant rat alpha internexin.
Epitope C-terminus
Clone 2E3
Host Mouse
Specificity Alpha internexin. Localized to the C-terminal 164 amino acids of rat alpha internexin.
Isotype IgG1
Species Reactivity
  • Human
  • Mammals
Antibody Type Monoclonal Antibody
Entrez Gene Number
Gene Symbol
  • INA
  • NF-66
  • NEF5
  • TXBP-1
  • Neurofilament-66
  • MGC12702
  • Alpha-internexin
  • Alpha-Inx
UniProt Number
UniProt Summary FUNCTION: SwissProt: Q16352 # Class-IV neuronal intermediate filament that is able to self-assemble. It is involved in the morphogenesis of neurons. It may form an independent structural network without the involvement of other neurofilaments or it may cooperate with NF-L to form the filamentous backbone to which NF-M and NF-H attach to form the cross-bridges.
SIZE: 499 amino acids; 55391 Da
TISSUE SPECIFICITY: Found predominantly in adult CNS.
DEVELOPMENTAL STAGE: Expressed in brain as early as the 16th week of gestation, and increased rapidly and reached a steady state level by the 18th week of gestation.
PTM: O-glycosylated (By similarity). & Phosphorylated upon DNA damage, probably by ATM or ATR.
SIMILARITY: SwissProt: Q16352 ## Belongs to the intermediate filament family.
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage Conditions Maintain at -20°C in undiluted aliquots for up to 6 months. Avoid repeated freeze/thaw cycles.
Packaging Information
Material Size 300 µL
Transport Information
Supplemental Information
Specifications

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