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Ms X Neurofilament 160 kDa Monoclonal Antibody

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货号：MAB5254

品牌：Millipore 密理博

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重要规格表

Species Reactivity Key Applications Host Format Antibody Type
Ch, Gp, M, Po, R, H IHC, IH(P), WB M Purified Monoclonal Antibody
Description
Catalogue Number MAB5254
Replaces CBL214
Brand Family Chemicon®
Trade Name
  • Chemicon
Description Anti-Neurofilament 160 kDa Antibody, clone NN18
Background Information Neurofilaments are a type of intermediate filament that serve as major elements of the cytoskeleton supporting the axon cytoplasm. They are the most abundant fibrillar components of the axon, being on average 3-10 times more frequent than axonal microtubules. Neurofilaments (10nm in dia.) are built from three intertwined protofibrils which are themselves composed of two tetrameric protofilament complexs of monomeric proteins. The neurofilament triplet proteins (68/70, 160, and 200 kDa) occur in both the central and peripheral nervous system and are usually neuron specific. The 68/70 kDa NF-L protein can self-assemble into a filamentous structure, however the 160 kDa NF-M and 200 kDa NF-H proteins require the presence of the 68/70 kDa NF-L protein to co-assemble. Neuromas, ganglioneuromas, gangliogliomas, ganglioneuroblastomas and neuroblastomas stain positively for neurofilaments. Although typically restricted to neurons, neurofilaments have been detected in paragangliomas and adrenal and extra-adrenal pheochromocytomas. Carcinoids, neuroendocrine carcinomas of the skin, and oat cell carcinomas of the lung also express neurofilaments. For more neurofilament information see Nervous System Cell Type Specific Marker chart online under the CHEMICON Technical Support section.
References
Product Information
Format Purified
Control
  • Brain
  • Cultured neurons
Presentation Purified mouse monoclonal IgG1 in buffer containing 0.02M Phosphate buffer, 0.25M NaCl with 0.1% sodium azide.
Applications
Application Anti-Neurofilament 160 kDa Antibody, clone NN18 is an antibody against Neurofilament 160 kDa for use in IH, IH(P) & WB.
Key Applications
  • Immunohistochemistry
  • Immunohistochemistry (Paraffin)
  • Western Blotting
Application Notes Immunohistochemistry:
5-10 µg/mL on frozen or paraffin embedded tissue. See protocols for details.

Western Blot:
1:1000. 7.5%-10% SDS-PAGE

Optimal working dilutions and protocols must be determined by end user.
Biological Information
Immunogen Purified neurofilament polypeptides.
Clone NN18
Concentration Please refer to the Certificate of Analysis for the lot-specific concentration.
Host Mouse
Specificity The antibody reacts with neurofilament 160 kD (Debus, E., 1982; Shaw, G., 1984).
Isotype IgG1
Species Reactivity
  • Chicken
  • Guinea Pig
  • Mouse
  • Pig
  • Rat
  • Human
Species Reactivity Note Expected to react with human based on sequence homology.
Antibody Type Monoclonal Antibody
Entrez Gene Number
Gene Symbol
  • NEFM
  • NF-M
  • NEF3
  • NFM
Purification Method Protein A Purfied
UniProt Number
UniProt Summary FUNCTION: SwissProt: P07197 # Neurofilaments usually contain three intermediate filament proteins: L, M, and H which are involved in the maintenance of neuronal caliber.
SIZE: 916 amino acids; 102448 Da
PTM: There are a number of repeats of the tripeptide K-S-P, NFM is phosphorylated on a number of the serines in this motif. It is thought that phosphorylation of NFM results in the formation of interfilament cross bridges that are important in the maintenance of axonal caliber. & Phosphorylation seems to play a major role in the functioning of the larger neurofilament polypeptides (NF-M and NF-H), the levels of phosphorylation being altered developmentally and coincident with a change in the neurofilament function.
SIMILARITY: SwissProt: P07197 ## Belongs to the intermediate filament family.
Molecular Weight 160 kDa
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Quality Assurance Routinely evaluated by Western Blot on PC12 lysates.

Western Blot Analysis:
1:500 dilution of this lot detected Neurofilament on 10 μg of PC12 lysates.
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage Conditions Stable for 6 months at 2-8ºC in undiluted aliquots from date of receipt.
Do not freeze.
Packaging Information
Material Size 40 µg
Transport Information
Supplemental Information
Specifications

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