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Ms X Hu ICAM-1

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货号：MAB2146Z

品牌：Millipore 密理博

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重要规格表

Species Reactivity Key Applications Host Format Antibody Type
H ELISA, FC, IP, ICC, IHC, FUNC M Purified Monoclonal Antibody
Description
Catalogue Number MAB2146Z
Brand Family Chemicon®
Trade Name
  • Chemicon
Description Anti-ICAM-1 Antibody, clone P2A4, Azide Free
Alternate Names
  • CD54
  • MAB2146
References
Product Information
Format Purified
Presentation Sterile-filtered lquid containing 0.2M phosphate buffer, 0.25M sodium chloride, no preservatives.
Applications
Application This Anti-ICAM-1 Antibody, clone P2A4, Azide Free is validated for use in ELISA, FC, IP, IC, IH, FUNC for the detection of ICAM-1.
Key Applications
  • ELISA
  • Flow Cytometry
  • Immunoprecipitation
  • Immunocytochemistry
  • Immunohistochemistry
  • Affects Function
Application Notes Immunohistochemistry: for use on acetone or paraformaldehyde fixed tissue

Immunocytochemistry: for use on B cells, PBL, T cells

Immunoprecipitation

FACS

ELISA

Inhibits ICAM-1 dependent adhesive interactions

Optimal working dilutions must be determined by end user.
Biological Information
Immunogen IL-1beta activated HUVEC (human)
Clone P2A4
Concentration Please refer to the Certificate of Analysis for the lot-specific concentration.
Host Mouse
Specificity Human ICAM-1
Isotype IgG1
Species Reactivity
  • Human
Antibody Type Monoclonal Antibody
Entrez Gene Number
Entrez Gene Summary ICAM1 (CD54) is typically expressed on endothelial cells and cells of the immune system. ICAM1 binds to integrins of type CD11a / CD18, or CD11b / CD18. ICAM1 is also exploited by Rhinovirus as a receptor.
Gene Symbol
  • ICAM1
  • P3.58
  • BB2
  • CD54
  • ICAM-1
UniProt Number
UniProt Summary FUNCTION: SwissProt: P05362 # ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2). In case of rhinovirus infection acts as a cellular receptor for the virus. Also acts as receptor for some coxsackieviruses.
SIZE: 532 amino acids; 57825 Da
SUBUNIT: Interacts with human herpesvirus 8 MIR2 protein (Probable).
SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.
PTM: Monoubiquitinated, which is promoted by MARCH9 and leads to endocytosis.
SIMILARITY: SwissProt: P05362 ## Belongs to the immunoglobulin superfamily. ICAM family. & Contains 5 Ig-like C2-type (immunoglobulin-like) domains.
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage Conditions Maintain at -20°C.
Packaging Information
Material Size 100 µg
Transport Information
Supplemental Information
Specifications

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