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DARPP-32 HIS-TAG

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货号：AG657

品牌：Millipore 密理博

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重要规格表

Key Applications Entrez Gene Number Uni Prot Number
WB NM_032192.2, NM_181505.2 Q9UD71
Description
Catalogue Number AG657
Brand Family Chemicon®
Trade Name
  • Chemicon
Description DARPP-32, recombinant, His-tagged
References
Product Information
Presentation 0.5 mg/mL in Tris-buffered saline containing 40% glycerol.
Applications
Key Applications
  • Western Blotting
Application Notes Phosphatase assays
Biological Information
Purity >90% by SDS-PAGE
Source Recombinant human DARPP-32, expressed in bacteria with a His-Tag linker.
Entrez Gene Number
Entrez Gene Summary Midbrain dopaminergic neurons play a critical role in multiple brain functions, and abnormal signaling through dopaminergic pathways has been implicated in several major neurologic and psychiatric disorders. One well-studied target for the actions of dopamine is DARPP32. In the densely dopamine- and glutamate-innervated rat caudate-putamen, DARPP32 is expressed in medium-sized spiny neurons (Ouimet and Greengard, 1990 [PubMed 2191086]) that also express dopamine D1 receptors (Walaas and Greengard, 1984 [PubMed 6319627]). The function of DARPP32 seems to be regulated by receptor stimulation. Both dopaminergic and glutamatergic (NMDA) receptor stimulation regulate the extent of DARPP32 phosphorylation, but in opposite directions (Halpain et al., 1990 [PubMed 2153935]). Dopamine D1 receptor stimulation enhances cAMP formation, resulting in the phosphorylation of DARPP32 (Walaas and Greengard, 1984 [PubMed 6319627]); phosphorylated DARPP32 is a potent protein phosphatase-1 (see MIM 176875) inhibitor (Hemmings et al., 1984 [PubMed 6087160]). NMDA receptor stimulation elevates intracellular calcium, which leads to activation of calcineurin and dephosphorylation of phospho-DARPP32, thereby reducing the phosphatase-1 inhibitory activity of DARPP32 (Halpain et al., 1990 [PubMed 2153935]).[supplied by OMIM]
Gene Symbol
  • PPP1R1B
  • DARPP-32
  • FLJ20940
  • DARPP32
UniProt Number
UniProt Summary FUNCTION: SwissProt: Q9UD71 # Inhibitor of protein-phosphatase 1.
SIZE: 204 amino acids; 22963 Da
SUBCELLULAR LOCATION: Cytoplasm.
PTM: Dopamine- and cyclic AMP-regulated neuronal phosphoprotein. & Phosphorylation of Thr-34 is required for activity (By similarity).
SIMILARITY: SwissProt: Q9UD71 ## Belongs to the protein phosphatase inhibitor 1 family.
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage Conditions Store at -20°C for up to 1 year.
Packaging Information
Material Size 50 µg
Transport Information
Supplemental Information
Specifications

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