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GM6001 [IIomastat] MMP Inhibitor

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货号：CC1000

品牌：Millipore 密理博

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Replacement Information
Description
Catalogue Number CC1000
Brand Family Chemicon®
Trade Name
  • Chemicon
Description GM6001 MMP Inhibitor
Overview Specificity: GM6001 MMP inhibitor, also known as Ilomastat or N-[(2R)-2-(hydroxamidocarbonylmethyl)-4-methylpentanoyl]-L-tryptophan methylamide, is a potent inhibitor of collagenases. Molecular weight: 388.47

Reported Ki values are as follows (see Galardy Ref):·

Human MMP-1 (Fibroblast collagenase): 0.4 nM·

Human MMP-3 (Stromelysin): 27 nM·

Human MMP-2 (72 kDa gelatinase): 0.5 nM·

Human MMP-8 (Neutrophil collagenase): 0.1 nM·

Human MMP-9 (92 kDa gelatinase): 0.2 nM

Typical working dilution for use in cultured cells is 10-25 μM. GM6001 will precipitate from aqueous solutions exceeding 100μM. Aqueous dilutions should be performed using low salt buffers to prevent precipitation of GM6001 from solution (Recommended dilution buffer: 50 mM Tris pH7.5, 150 mM NaCl, and 20 mM CaCl2.2H20). It is recommended that the concentration of GM6001 in aqueous working solutions is determined upon dilution and confirmed prior to each use. Relative concentrations of GM6001 in aqueous solutions may be determined by measuring the absorbance of the solution (tyrosine) at 280 nm.
References
Product Information
Presentation Provided at 1 mg/mL (2.5 mM) in DMSO.
Applications
Application The GM6001 MMP Inhibitor controls the biological activity of MMP. This small molecule/inhibitor is primarily used for Biochemicals applications.
Key Applications
  • Inhibits Activity/Function
Biological Information
Concentration 1 mg/mL (2.5 mM) in DMSO
Entrez Gene Number
Entrez Gene Summary Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. However, the enzyme encoded by this gene is stored in secondary granules within neutrophils and is activated by autolytic cleavage. Its function is degradation of type I, II and III collagens. The gene is part of a cluster of MMP genes which localize to chromosome 11q22.3.
Gene Symbol
  • MMP1
  • CLG
  • MMP-1
  • CLGN
  • EC 3.4.24.7 [Contains: 22 kDa interstitial collagenase
  • 27 kDa interstitial collagenase].
Protein Target Interstitial collagenase
UniProt Number
UniProt Summary FUNCTION: SwissProt: P22894 # Can degrade fibrillar type I, II, and III collagens.
COFACTOR: Binds 3 calcium ions per subunit. & Binds 2 zinc ions per subunit.
SIZE: 467 amino acids; 53412 Da
SUBCELLULAR LOCATION: Cytoplasmic granule. Note=Stored in intracellular granules.
TISSUE SPECIFICITY: Neutrophils.
DOMAIN: SwissProt: P22894 The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme.
SIMILARITY: Belongs to the peptidase M10A family. & Contains 4 hemopexin-like domains.
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage Conditions Maintain frozen at -20°C in DMSO for up to 12 months. Avoid storage once diluted into aqueous solutions.
Packaging Information
Material Size 1 mg
Transport Information
Supplemental Information
Specifications

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