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Ms X Hu Cartilage Proteoglycan (Adult)

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货号：MAB2015

品牌：Millipore 密理博

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重要规格表

Species Reactivity Key Applications Host Format Antibody Type
B, Ca, Ch, H, Po, Rb, Sh ELISA, RIA, WB, IHC M Ascites Monoclonal Antibody
Description
Catalogue Number MAB2015
Brand Family Chemicon®
Trade Name
  • Chemicon
Description Anti-Cartilage Proteoglycan Antibody, adult, clone EFG-4
References
Product Information
Format Ascites
Presentation Ascites fluid
Applications
Application Anti-Cartilage Proteoglycan Antibody, adult, clone EFG-4 detects level of Cartilage Proteoglycan & has been published & validated for use in ELISA, RIA, WB, IH.
Key Applications
  • ELISA
  • Radioimmunoassay
  • Western Blotting
  • Immunohistochemistry
Application Notes Western blot: 1:1,00 - 1:200
Immunohistochemistry: 1:50 - 250
ELISA: 1:250 - 1: 2500
RIA: 1:20,000 - 1:40,000
Optimal working dilutions must be determined by the end user. I/
Biological Information
Immunogen Human adult cartilage proteoglycan.
Epitope adult
Clone EFG-4
Host Mouse
Specificity Recognizes the short peptides substituted with keratan sulfate side chains and within the core protein of proteoglycans in articular cartilages, chicken limb bud and cornea. Does not cross-react with human fetal cartilage proteoglycans.
Isotype IgG1κ
Species Reactivity
  • Bovine
  • Canine
  • Chicken
  • Human
  • Pig
  • Rabbit
  • Sheep
Antibody Type Monoclonal Antibody
Entrez Gene Number
Entrez Gene Summary This gene is a member of the aggrecan/versican proteoglycan family. The encoded protein is an integral part of the extracellular matrix in cartilagenous tissue and it withstands compression in cartilage. Mutations in this gene may be involved in skeletal dysplasia and spinal degeneration. Multiple alternatively spliced transcript variants that encode different protein isoforms have been observed in this gene.
Gene Symbol
  • ACAN
  • MSK16
  • SEDK
  • CSPCP
  • AGCAN
  • AGC1
  • CSPG1
  • CSPGCP
Non-Reactive Species
  • Mouse
  • Rat
UniProt Number
UniProt Summary FUNCTION: SwissProt: P16112 # This proteoglycan is a major component of extracellular matrix of cartilagenous tissues. A major function of this protein is to resist compression in cartilage. It binds avidly to hyaluronic acid via an N-terminal globular region.
SIZE: 2415 amino acids; 250193 Da
SUBUNIT: Interacts with FBLN1 (By similarity).
SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular matrix (By similarity).
TISSUE SPECIFICITY: Restricted to cartilages.
DEVELOPMENTAL STAGE: Expression was detected in chondrocytes throughout the developing skeleton.
DOMAIN: SwissProt: P16112 Two globular domains, G1 and G2, comprise the N-terminus of the proteoglycan, while another globular region, G3, makes up the C-terminus. G1 contains Link domains and thus consists of three disulfide-bonded loop structures designated as the A, B, B' motifs. G2 is similar to G1. The keratan sulfate (KS) and the chondroitin sulfate (CS) attachment domains lie between G2 and G3.
PTM: Contains mostly chondroitin sulfate, but also keratan sulfate chains, N-linked and O-linked oligosaccharides. The release of aggrecan fragments from articular cartilage into the synovial fluid at all stages of human osteoarthritis is the result of cleavage by aggrecanase.
DISEASE: SwissProt: P16112 # Defects in AGC1 are the cause of spondyloepiphyseal dysplasia type Kimberley (SEDK) [MIM:608361]. Spondyloepiphyseal dysplasias are a heterogeneous group of congenital chondrodysplasias that specifically affect epiphyses and vertebrae. The autosomal dominant SEDK is associated with premature degenerative arthropathy.
SIMILARITY: Belongs to the aggrecan/versican proteoglycan family. & Contains 1 C-type lectin domain. & Contains 1 EGF-like domain. & Contains 1 Ig-like V-type (immunoglobulin-like) domain. & Contains 4 Link domains. & Contains 1 Sushi (CCP/SCR) domain.
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage Conditions Maintain at -20°C in aliquots for up to 12 months. Avoid repeated freeze/thaw cycles.
Packaging Information
Material Size 100 µL
Transport Information
Supplemental Information
Specifications

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