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Ms X Laminin beta1

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货号：MAB2041

品牌：Millipore 密理博

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重要规格表

Species Reactivity Key Applications Host Format Antibody Type
H WB, FUNC M Ascites Monoclonal Antibody
Description
Catalogue Number MAB2041
Brand Family Chemicon®
Trade Name
  • Chemicon
Description Anti-Laminin β1 Antibody, clone 3E5
Alternate Names
  • Laminin B1 Chain
References
Product Information
Format Ascites
Presentation Ascites liquid; containing no preservatives.
Applications
Application This Anti-Laminin β1 Antibody, clone 3E5 is validated for use in WB, FUNC for the detection of Laminin β1.
Key Applications
  • Western Blotting
  • Affects Function
Application Notes 3E5 partially blocks the neurite-promoting activity of laminin.

The antibody can be used in immunoblotting and reacts with pepsin fragments of human laminin, the predominant polypeptides being approximately 400 kDa. MAB2041 stained basement membranes in placenta and immunoprecipitated laminin from media of cultured choriocarcinoma cells.

Optimal working dilutions must be determined by end user.
Biological Information
Clone 3E5
Host Mouse
Specificity Laminin beta 1. Reactive at the end of the rod-like portion of the long arm adjacent to the globular domain, as shown by electron microscopy after rotary shadowing. The antibody has been developed against a truncated form of human laminin isolated from placenta.
Isotype Ig
Species Reactivity
  • Human
Antibody Type Monoclonal Antibody
Entrez Gene Number
Gene Symbol
  • LAMB2
  • S-laminin
  • LAMS
UniProt Number
UniProt Summary FUNCTION: SwissProt: P55268 # Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components.
SIZE: 1798 amino acids; 195981 Da
SUBUNIT: Laminin is a complex glycoprotein, consisting of three different polypeptide chains (alpha, beta, gamma), which are bound to each other by disulfide bonds into a cross-shaped molecule comprising one long and three short arms with globules at each end. Beta-2 is a subunit of laminin-3 (S-laminin), laminin-4 (S- merosin), and laminin-7 (KS-laminin).
SUBCELLULAR LOCATION: Secreted, extracellular space. Note=S- laminin is concentrated in the synaptic cleft of the neuromuscular junction.
DOMAIN: SwissProt: P55268 The alpha-helical domains I and II are thought to interact with other laminin chains to form a coiled coil structure. & Domains VI and IV are globular.
DISEASE: SwissProt: P55268 # Defects in LAMB2 are the cause of Pierson syndrome [MIM:609049]; also known as microcoria-congenital nephrotic syndrome. Pierson syndrome is characterized by nephrotic syndrome with neonatal onset, diffuse mesangial sclerosis and eye abnormalities with microcoria as the leading clinical feature. Death usually occurs within the first weeks of life. Disease severity depends on the mutation type: nontruncating LAMB2 mutations may display variable phenotypes ranging from a milder variant of Pierson syndrome to isolated congenital nephrotic syndrome. & Defects in LAMB2 are a cause of congenital nephrotic syndrome [MIM:609049]. Congenital nephrotic syndrome constitutes a heterogeneous group of conditions having in common the disruption of normal glomerular permselectivity. Congenital nephrotic syndrome due to LAMB2 mutations may be associated with ocular abnormalities.
SIMILARITY: Contains 13 laminin EGF-like domains. & Contains 1 laminin IV type B domain. & Contains 1 laminin N-terminal domain.
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage Conditions Maintain frozen at -20°C in undiluted aliquots for up to 12 months.
Packaging Information
Material Size 100 µL
Transport Information
Supplemental Information
Specifications

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