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Anti-Synapsin I phosphoSer603 Affinity Purified (Rabbit Polyclonal)

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货号：AB5883

品牌：Millipore 密理博

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重要规格表

Species Reactivity Key Applications Host Format Antibody Type
R WB Rb Affinity Purified Polyclonal Antibody
Description
Catalogue Number AB5883
Brand Family Chemicon®
Trade Name
  • Chemicon
Description Anti-Synapsin I Antibody, phosphoSer 603
References
Product Information
Format Affinity Purified
Presentation Affinity purified immunoglobulin presented as a liquid in 10 mM HEPES, pH 7.5, with 150 mM NaCl, 100 μg/mL BSA and 50% glycerol.
Applications
Application Anti-Synapsin I Antibody, phosphoSer 603 detects level of Synapsin I & has been published & validated for use in WB.
Key Applications
  • Western Blotting
Application Notes Western blot: 1:1,000. Rat brain lysate shows a ~78-80kDa band.

Optimal working dilutions must be determined by the end user.
Biological Information
Immunogen Synthetic peptide corresponding to amino acids surrounding the phosphoSer603 of rat Synapsin I. The immunogen sequence is identical in human, mouse and Xenopus.
Epitope phosphoSer 603
Host Rabbit
Specificity Synapsin I, phosphoSer603. This is the site phosphorylated by Calcium calmodulin kinase II. The antibody recognizes the ~78 kD Synapsin I, phosphoSer603 protein. Immunolabeling is blocked by the immunogen peptide but no by the corresponding non-phospho peptide.
Species Reactivity
  • Rat
Antibody Type Polyclonal Antibody
Entrez Gene Number
Entrez Gene Summary This gene is a member of the synapsin gene family. Synapsins encode neuronal phosphoproteins which associate with the cytoplasmic surface of synaptic vesicles. Family members are characterized by common protein domains, and they are implicated in synaptogenesis and the modulation of neurotransmitter release, suggesting a potential role in several neuropsychiatric diseases. This member of the synapsin family plays a role in regulation of axonogenesis and synaptogenesis. The protein encoded serves as a substrate for several different protein kinases and phosphorylation may function in the regulation of this protein in the nerve terminal. Mutations in this gene may be associated with X-linked disorders with primary neuronal degeneration such as Rett syndrome. Alternatively spliced transcript variants encoding different isoforms have been identified.
Gene Symbol
  • SYN1
  • SYN1a
  • Synapsin-1
  • SYNI
  • SYN1b
Modifications
  • Phosphorylation
UniProt Number
UniProt Summary FUNCTION: SwissProt: P17600 # Neuronal phosphoprotein that coats synaptic vesicles, binds to the cytoskeleton, and is believed to function in the regulation of neurotransmitter release. The complex formed with NOS1 and CAPON proteins is necessary for specific nitric-oxid functions at a presynaptic level.
SIZE: 705 amino acids; 74111 Da
SUBUNIT: Homodimer. Interacts with CAPON. Forms a ternary complex with NOS1 (By similarity).
SUBCELLULAR LOCATION: Cell junction, synapse.
PTM: Substrate of at least four different protein kinases. It is probable that phosphorylation plays a role in the regulation of synapsin-1 in the nerve terminal. Phosphorylated upon DNA damage, probably by ATM or ATR.
DISEASE:SwissProt: P17600 # Defects in SYN1 are a cause of X-linked recessive epilepsy associated with variable learning disabilities and behavior disorders [MIM:300491].
SIMILARITY: SwissProt: P17600 ## Belongs to the synapsin family.
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage Conditions Maintain at -20°C in undiluted for up to 6 months from date of receipt. Avoid repeated freeze/thaw cycles. Do not store in a self-defrosting freezer.
Packaging Information
Material Size 100 µL
Transport Information
Supplemental Information
Specifications

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