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Guinea Pig Anti-Protein Gene Product 9.5 (PGP9.5) Polyclonal

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货号：AB5898

品牌：Millipore 密理博

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重要规格表

Species Reactivity Key Applications Host Format Antibody Type
H, M, R IHC Gp Serum Polyclonal Antibody
Description
Catalogue Number AB5898
Brand Family Chemicon®
Trade Name
  • Chemicon
Description Anti-Protein Gene Product 9.5 Antibody
Alternate Names
  • PGP 9.5
  • UCH-L1
References
Product Information
Format Serum
Control
  • Brain tissue
Presentation Liquid. Contains 0.05% sodium azide.
Applications
Application Anti-Protein Gene Product 9.5 Antibody detects level of Protein Gene Product 9.5 & has been published & validated for use in IH.
Key Applications
  • Immunohistochemistry
Application Notes Immunohistochemistry: 1:500.

Optimal working dilutions must be determined by end user.

blocking buffer for 1 hour at room temperature. Primary antibody was diluted in blocking buffer to the appropriate working dilution. Blocking buffer was removed and the slides were then incubated at 4°C for 18-24 hours with AB5898 (1:500). After rinsing in PBS 3 times sections were incubated for 60 minutes at room temperature with Cy3-conjugated secondary antibodies. After mounting in a mixture of PBS and glycerol (1:3) containing 0.1% p-phenylenediamine, sections were examined with a Nikon Microphot-SA epifluorescence microscope.
Biological Information
Immunogen A 17 amino acid peptide corresponding to amino acids 175-191 from soluble cytoplasmic human PGP9.5.
Concentration Please refer to the Certificate of Analysis for the lot-specific concentration.
Host Guinea Pig
Specificity Recognizes Protein Gene Product 9.5 (PGP9.5).
Species Reactivity
  • Human
  • Mouse
  • Rat
Antibody Type Polyclonal Antibody
Entrez Gene Number
Entrez Gene Summary UCHL1 is a member of a gene family whose products hydrolyze small C-terminal adducts of ubiquitin to generate the ubiquitin monomer. Expression of UCHL1 is highly specific to neurons and to cells of the diffuse neuroendocrine system and their tumors. It is present in all neurons (Doran et al., 1983 [PubMed 6343558]).[supplied by OMIM]
Gene Symbol
  • UCHL1
  • PARK5
  • UCH-L1
  • Uch-L1
  • PGP9.5
  • EC 3.4.19.12
  • EC 6.-.-.-
Purification Method Unpurified
UniProt Number
UniProt Summary FUNCTION: SwissProt: P09936 # Ubiquitin-protein hydrolase involved both in the processing of ubiquitin precursors and of ubiquitinated proteins. This enzyme is a thiol protease that recognizes and hydrolyzes a peptide bond at the C-terminal glycine of ubiquitin. Also binds to free monoubiquitin and may prevent its degradation in lysosomes. The homodimer may have ATP-independent ubiquitin ligase activity.
SIZE: 223 amino acids; 24824 Da
SUBUNIT: Homodimer. Interacts with SNCA (By similarity). Interacts with COPS5.
SUBCELLULAR LOCATION: Cytoplasm.
TISSUE SPECIFICITY: Found in neuronal cell bodies and processes throughout the neocortex (at protein level). Expressed in neurons and cells of the diffuse neuroendocrine system and their tumors. Weakly expressed in ovary.
PTM: O-glycosylated (By similarity).
DISEASE: SwissProt: P09936 # Oxidation of Met-1, Met-6, Met-12, Met-124 and Met-179 to methionine sulfoxide, and oxidation of Cys-220 to cysteine sulfonic acid have been observed in brains from Alzheimer disease (AD) and Parkinson disease (PD) patients. In AD, UCHL1 was found to be associated with neurofibrillary tangles.
SIMILARITY: SwissProt: P09936 ## Belongs to the peptidase C12 family.
MISCELLANEOUS: In contrast to UCHL3, does not hydrolyze a peptide bond at the C-terminal glycine of NEDD8.
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage Conditions Maintain for 1 year at -20°C from date of shipment. Aliquot to avoid repeated freezing and thawing. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Packaging Information
Material Size 50 µL
Transport Information
Supplemental Information
Specifications

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