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Rb X HERG Potassium Channel

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货号：AB5908-50UL

品牌：Millipore 密理博

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重要规格表

Species Reactivity Key Applications Host Format Antibody Type
H ICC, IP, WB Rb Affinity Purified Polyclonal Antibody
Description
Catalogue Number AB5908-50UL
Brand Family Chemicon®
Trade Name
  • Chemicon
Description Anti-Potassium Channel HERG Antibody, CT
Alternate Names
  • Erg1
  • Kcnh2
  • Kv11.1
  • Ether-a-go-go Related Channel
  • Voltage Gated K+ Channel Subfamily H Member 2
References
Product Information
Format Affinity Purified
Control
  • CONTROL ANTIGEN: Included free of charge with the antibody is 60 μg of fusion protein (35 kDa). The stock solution of the antigen can be made up using 100 μL of PBS. For negative control, preincubate 3 μg of fusion protein with 1 μg of antibody for one hour at room temperature. For positive control, use 20 ng of fusion protein per lane. Optimal concentrations must be determined by the end user.
Presentation Affinity purified immunoglobulin. Lyophilized from phosphate buffered saline, pH 7.4, containing 1% BSA, and 0.025% sodium azide as a preservative. Reconstitute with 50 μL of sterile deionized water. Centrifuge antibody preparation before use (10,000 xg for 5 min).
Applications
Application This Anti-Potassium Channel HERG Antibody, C-terminus is validated for use in IC, IP, WB for the detection of Potassium Channel HERG.
Key Applications
  • Immunocytochemistry
  • Immunoprecipitation
  • Western Blotting
Application Notes Western blot: 1:200-400 using ECL on HERG transfected HEK293 cells.
Immunocytochemistry: 1:100 to 1:200.
Immunoprecipitation: 2-5 μg/mL extract.

Dilutions should be made using a carrier protein such as BSA (1-3%).

Optimal working dilutions must be determined by the end user.
Biological Information
Immunogen GST fusion protein corresponding to amino acids 1106-1159 of human erg1 (HERG). The immunogen shares similarity with rat erg2 (22/54) and rat erg3 (21/54).
Epitope C-terminus
Concentration Please refer to the Certificate of Analysis for the lot-specific concentration.
Host Rabbit
Specificity Recognizes HERG. The antibody recognizes the HERG1b splice variant but not splice variants HERG1-3 or HERG-4.
Species Reactivity
  • Human
Antibody Type Polyclonal Antibody
Entrez Gene Number
Entrez Gene Summary This gene encodes a voltage-activated potassium channel belonging to the eag family. It shares sequence similarity with the Drosophila ether-a-go-go (eag) gene. Mutations in this gene can cause long QT syndrome type 2 (LQT2). Transcript variants encoding distinct isoforms have been identified.
Gene Symbol
  • KCNH2
  • ERG1
  • LQT2
  • erg1
  • HERG
  • SQT1
  • H-ERG
  • Kv11.1
  • HERG1
  • Erg1
  • ERG
UniProt Number
UniProt Summary FUNCTION: SwissProt: Q12809 # Pore-forming (alpha) subunit of voltage-gated inwardly rectifying potassium channel. Channel properties are modulated by cAMP and subunit assembly. Mediates the rapidly activating component of the delayed rectifying potassium current in heart (IKr). Isoform 3 has no channel activity by itself, but modulates channel characteristics when associated with isoform 1.
SIZE: 1159 amino acids; 126655 Da
SUBUNIT: The potassium channel is probably composed of a homo- or heterotetrameric complex of pore-forming alpha subunits that can associate with modulating beta subunits. Heteromultimer with KCNH6/ERG2 and KCNH7/ERG3. Interacts with ALG10B (By similarity). Heteromultimer with KCNE1 and KCNE2.
SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
TISSUE SPECIFICITY: Highly expressed in heart and brain.
DOMAIN:SwissProt: Q12809 The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position.
PTM: Phosphorylated on serine and threonine residues. Phosphorylation by PKA inhibits ion conduction.
DISEASE: SwissProt: Q12809 # Defects in KCNH2 are the cause of long QT syndrome type 2 (LQT2) [MIM:152427]. Long QT syndromes are heart disorders characterized by a prolonged QT interval on the ECG and polymorphic ventricular arrhythmias. They cause syncope and sudden death in response to exercise or emotional stress. Deafness is often associated with LQT2. & Defects in KCNH2 are the cause of short QT syndrome type 1 (SQT1) [MIM:609620]. Short QT syndromes are heart disorders characterized by idiopathic persistently and uniformly short QT interval on ECG in the absence of structural heart disease in affected individuals. They cause syncope and sudden death.
SIMILARITY: Belongs to the potassium channel family. H (Eag) subfamily. & Contains 1 cyclic nucleotide-binding domain. & Contains 1 PAC (PAS-associated C-terminal) domain. & Contains 1 PAS (PER-ARNT-SIM) domain.
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage Conditions Maintain lyophilized material at -20°C for up to 12 months from date of receipt. After reconstitution maintain at -20°C in undiluted aliquots for up to 6 months. Avoid repeated freeze/thaw cycles.
Packaging Information
Material Size 50 µL
Transport Information
Supplemental Information
Specifications

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