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Anti-Caspr, clone K65/35 (mouse monoclonal)

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货号：MABN69

品牌：Millipore 密理博

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重要规格表

Species Reactivity Key Applications Host Format Antibody Type
R IHC, WB M Purified Monoclonal Antibody
Description
Catalogue Number MABN69
Description Anti-Caspr Antibody, clone K65/35
Alternate Names
  • contactin associated protein 1
  • neurexin 4
  • neurexin-4
  • contactin-associated protein 1
  • Neurexin IV
  • Neurexin-4
Background Information Contactin-associated protein 1(Caspr) is a single-pass type I membrane protein belonging to the neurexin family and is comprised of one F5/8 type C domain, one fibrinogen C-terminal domain, two EGF-like domains, and four laminin G-like domains. Caspr is well documented for its interaction with contactin, an interaction that is crucial to the transport of Caspr to the plasma membrane, the mylination of glial cells, and the generation of axoglial junctions. Studies also suggest that Caspr may play a regulatory role in the cell surface expression of contactin and its targeting to different axonal domains. Expression of Caspr is largely observed in the brain, mainly in CNS myelinated nerve fibers within paranodal axoglial junctions.
References
Product Information
Format Purified
Control
  • Rat brain membrane tissue lysate
Presentation Purified mouse monoclonal IgG1κ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Applications
Application Anti-Caspr Antibody, clone K65/35 is an antibody against Caspr for use in IH & WB.
Key Applications
  • Immunohistochemistry
  • Western Blotting
Application Notes Immunohistochemistry Analysis: 1:300 dilution from a previous lot detected Caspr in rat cerebellum and rat hippocampus tissues.
Biological Information
Immunogen Recombinant protein corresponding to rat Caspr.
Clone K65/35
Concentration Please refer to the Certificate of Analysis for the lot-specific concentration.
Host Mouse
Isotype IgG1κ
Species Reactivity
  • Rat
Species Reactivity Note Demonstrated to react with rat. Predicted to react with mouse based on 100% sequence homology.
Antibody Type Monoclonal Antibody
Entrez Gene Number
Entrez Gene Summary Forms a complex with contactin; may mediate communication between glial cells and neurons during development [RGD].
Gene Symbol
  • CNTNAP
  • Caspr1
  • caspr1
  • P190
  • p190
  • NRXN4
  • CASPR
Purification Method Protein G
UniProt Number
UniProt Summary FUNCTION: Seems to play a role in the formation of functional distinct domains critical for saltatory conduction of nerve impulses in myelinated nerve fibers. Seems to demarcate the paranodal region of the axo-glial junction. In association with contactin may have a role in the signaling between axons and myelinating glial cells.

SUBUNIT STRUCTURE: Interacts with contactin in cis form.

SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein (Potential).

TISSUE SPECIFICTY: Predominantly expressed in brain. In myelinated nerve fibers of the CNS predominantly found in paranodal axoglial junctions. In unmyelinated nerve fibers of the CNS diffusely distributed along the entire surface. Weak expression is detected in ovary, pancreas, colon, lung, heart, intestine and testis.

DEVELOPMENTAL STAGE: Detected on postnatal day 7 in cerebellum. Follows a caudorostral progession according to the myelination process. Appears to redistribute from the internode to the paranodal region during myelin compaction and maturation. Expression reaches maximal levels between days 14 and 18 and remains at the same levels until adulthood.

SEQUENCE SIMILARITIES: Belongs to the neurexin family.

Contains 2 EGF-like domains.

Contains 1 F5/8 type C domain.

Contains 1 fibrinogen C-terminal domain.

Contains 4 laminin G-like domains.
Molecular Weight ~ 220 kDa observed
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Quality Assurance Evaluated by Western Blot in rat brain membrane tissue lysate.

Western Blot Analysis: 0.5 µg/mL of this antibody detected Caspr on 10 µg of rat brain membrane tissue lysate.
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage Conditions Stable for 1 year at 2-8°C from date of receipt.
Packaging Information
Material Size 100 µg
Transport Information
Supplemental Information
Specifications

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