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Anti-IFNAR-1, clone MARI-5A3 (mouse monoclonal)

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货号：04-151

品牌：Millipore 密理博

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重要规格表

Species Reactivity Key Applications Host Format Antibody Type
M FC, IP, WB, NEUT M Purified Monoclonal Antibody
Description
Catalogue Number 04-151
Description Anti-IFNAR-1 Antibody, clone MARI-5A3
Alternate Names
  • interferon (alpha, beta and omega) receptor 1
  • beta-type antiviral protein
  • alpha-type antiviral protein
  • Type I interferon receptor 1
  • Cytokine receptor family 2 member 1
  • interferon-beta receptor 1
  • Cytokine receptor class-II member 1
  • IFN-alpha-REC
  • interferon-alpha/beta receptor alpha chain
  • IFN-alpha/beta receptor 1
  • interferon alpha/beta receptor 1
  • human interferon-alpha receptor (HuIFN-alpha-Rec)
Background Information Interferon alpha/beta receptor 1 (IFNAR-1) is a single-pass type I membrane protein containing three fibronectin type-III domains and is a member of the type II cytokine receptor family. IFNAR-1 serves as an interferon receptor specific to interferons alpha and beta, a family of type I interferons critical to the promotion and the linking of adaptive and innate immune response. Type I interferons all bind to a heterodimeric receptor composed of two subunits, IFNAR-1 and IFNAR-2. The binding of the type I IFNs initializes tyrosine phosphorylation for several proteins such as; IFNR alpha/beta subunits, JAKs, STAT, and TYK2 proteins.
References
Product Information
Format Purified
Control
  • BALB/c splenocytes
Presentation Purified mouse monoclonal IgG1κ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Applications
Application Anti-IFNAR-1 Antibody, clone MARI-5A3 is an antibody against IFNAR-1 for use in FC, IP, WB, NEUT.
Key Applications
  • Flow Cytometry
  • Immunoprecipitation
  • Western Blotting
  • Neutralizing
Application Notes Western Blot Analysis: A previous lot was used by an independent laboratory in WB. (Sheehan, K., et al. (2006). Journal of Interferon & Cytokine Research. 26:804-819.)

Immunoprecipitation Analysis: A previous lot was used by an independent laboratory in IP. (Sheehan, K., et al. (2006). Journal of Interferon & Cytokine Research. 26:804-819.)

Flow Cytometry Analysis: A previous lot was used by an independent laboratory in FC. (Sheehan, K., et al. (2006). Journal of Interferon & Cytokine Research. 26:804-819.)

Neutralizing Assay: A previous lot was used by an independent laboratory in neutralization studies. (Sheehan, K., et al. (2006). Journal of Interferon & Cytokine Research. 26:804-819.)
Biological Information
Immunogen Recombinant protein corresponding to the extracellular domain of mouse IFNAR-1.
Epitope Extracellular Domain
Clone MARI-5A3
Concentration Please refer to the Certificate of Analysis for the lot-specific concentration.
Host Mouse
Specificity This antibody recognizes the extracellular domain of IFNAR-1.
Isotype IgG1κ
Species Reactivity
  • Mouse
Antibody Type Monoclonal Antibody
Entrez Gene Number
Gene Symbol
  • IFRC
  • IFNAR1
  • IFNBR
  • IFN-R-1
  • IFNAR
  • AVP
  • CRF2-1
Purification Method Protein G Purified
UniProt Number
UniProt Summary FUNCTION: Receptor for interferons alpha and beta. Binding to type I IFNs triggers tyrosine phosphorylation of a number of proteins including JAKs, TYK2, STAT proteins and IFNR alpha- and beta-subunits themselves.

SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.

SEQUENCE SIMILARITIES: Belongs to the type II cytokine receptor family.

Contains 3 fibronectin type-III domains.
Molecular Weight 63 kDa calculated
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Quality Assurance Evaluated by Flow Cytometry in BALB/c splenocytes.

Flow Cytometry Analysis: 5 µg of this antibody detected IFNAR-1 in BALB/c splenocytes.
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage Conditions Stable for 1 year at 2-8°C from date of receipt.
Packaging Information
Material Size 100 µg
Transport Information
Supplemental Information
Specifications

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