Anti-phospho-STAT5A/B (Tyr694/699), clone A11W (rabbit monoclonal) - 炼石商城

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Anti-phospho-STAT5A/B (Tyr694/699), clone A11W (rabbit monoclonal)

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货号：04-886

品牌：Millipore 密理博

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重要规格表

Species Reactivity	Key Applications	Host	Format	Antibody Type
R, H, M, B, Chp	WB	Rb	Culture Supernatant	Monoclonal Antibody

Description
Catalogue Number	04-886
Replaces	05-886
Description	Anti-phospho-STAT5A/B (Tyr694/699) Antibody, clone A11W, rabbit monoclonal
Alternate Names	signal transducer and activator of transcription 5A signal transducer and activator of transcription 5B transcription factor STAT5B
Background Information	The STAT proteins (signal transducer and activator of transcription) comprise a family of transcription factors. STATs are activated through tyrosine phosphorylation, mainly by JAK kinases, which results in their dimerization, nuclear translocation and regulation of gene expression. STAT5 activity is induced by numerous cytokines and growth factors. While STAT5A and STAT5B share 96% amino acid homology, the two isoforms have distinct physiological functions. Phosphorylation of tyrosine 694/699 is a key marker of STAT5A/B activation.

References

Product Information
Format	Culture Supernatant
Control	PDGF treated 3T3/NIH cells
Presentation	Cultured supernatant containing 0.05% sodium azide.

Applications
Application	Detect phospho-STAT5A/B (Tyr694/699) using this Anti-phospho-STAT5A/B (Tyr694/699) Antibody, clone A11W validated for use in WB.
Key Applications	Western Blotting
Applications Not Recommended	Immunoprecipitation

Biological Information
Immunogen	KLH-conjugated, synthetic peptide containing the sequence DGpYVK in which pY corresponds to phospho-tyrosine at residue 694 of human STAT5A or residue 699 of STAT5B.
Epitope	pTyr694/699
Clone	A11W
Host	Rabbit
Specificity	Phospho-STAT5A/B (Tyr694/699).
Isotype	IgG
Species Reactivity	Rat Human Mouse Bovine Chimpanzee
Antibody Type	Monoclonal Antibody
Entrez Gene Number	NM_003152 NM_012448
Entrez Gene Summary	The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein mediates the signal transduction triggered by various cell ligands, such as IL2, IL4, CSF1, and different growth hormones. It has been shown to be involved in diverse biological processes, such as TCR signaling, apoptosis, adult mammary gland development, and sexual dimorphism of liver gene expression. This gene was found to fuse to retinoic acid receptor-alpha (RARA) gene in a small subset of acute promyelocytic leukemias (APLL). The dysregulation of the signaling pathways mediated by this protein may be the cause of the APLL. [provided by RefSeq]
Gene Symbol	MGF STAT5 STAT5
Modifications	Phosphorylation
UniProt Number	P42229
UniProt Summary	FUNCTION: Carries out a dual function: signal transduction and activation of transcription. Binds to the GAS element and activates PRL-induced transcription. SUBUNIT: Forms a homodimer or a heterodimer with a related family member. Binds NR3C1 By similarity. Interacts with NCOA1 and SOCS7. SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Note= Translocated into the nucleus in response to phosphorylation. PTM: Tyrosine phosphorylated in response to IL-2, IL-3, IL-7, IL-15, GM-CSF, growth hormone, prolactin, erythropoietin and thrombopoietin. Tyrosine phosphorylation is required for DNA-binding activity and dimerization. Serine phosphorylation is also required for maximal transcriptional activity By similarity. SIMILARITY: Belongs to the transcription factor STAT family. Contains 1 SH2 domain.
Molecular Weight	~95 kDa

Physicochemical Information

Dimensions

Materials Information

Toxicological Information

Safety Information according to GHS

Safety Information

Product Usage Statements
Quality Assurance	Evaluated by western blot on RIPA lysates from 3T3/NIH cells untreated and treated with PDGF. Western Blot Analysis: A 1:1,000-1:2,000 dilution of this antibody detected phospho-STAT5A/B (Tyr694/699) in lysates from 3T3/NIH cells treated with PDGF.
Usage Statement	Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Storage and Shipping Information
Storage Conditions	Stable for 1 year at -20ºC from date of receipt. Handling Recommendations: Upon receipt, and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.

Packaging Information
Material Size	100 µL

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