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Rb X IL-1 beta

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货号：AB10626

品牌：Millipore 密理博

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Replacement Information

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重要规格表

Species Reactivity Key Applications Host Format Antibody Type
Po WB Rb Purified Polyclonal Antibody
Description
Catalogue Number AB10626
Replaces 04-462; MABF22
Brand Family Chemicon®
Trade Name
  • Chemicon
Description Anti-IL-1 β Antibody
Background Information This antibody recognizes natural and recombinant swine IL-1 . either a 269 AA or a 271 AA (17 kDa) protein with no disulfide bonds. There are two distinct molecular forms of IL-1 (IL-1 and IL-1 ) derived from two different genes.
References
Product Information
Format Purified
Presentation Rabbit polyclonal antibodies in phosphate buffered saline, pH 7.2.
Applications
Application Anti-IL-1 β Antibody is an antibody against IL-1 β for use in WB.
Key Applications
  • Western Blotting
Application Notes This antibody is suitable for use in Western blot analysis at 0.5 - 2.0 ug/mL.
This antibody is non-neutralizing when tested by proliferation assay.
Biological Information
Immunogen Recombinant swine IL-1β.
Concentration Please refer to the Certificate of Analysis for the lot-specific concentration.
Host Rabbit
Specificity Recognizes IL-1 Beta.
Species Reactivity
  • Pig
Species Reactivity Note Swine. Other species were not tested.
Antibody Type Polyclonal Antibody
Entrez Gene Number
Entrez Gene Summary The protein encoded by this gene is a member of the interleukin 1 cytokine family. This cytokine is produced by activated macrophages as a proprotein, which is proteolytically processed to its active form by caspase 1 (CASP1/ICE). This cytokine is an important mediator of the inflammatory response, and is involved in a variety of cellular activities, including cell proliferation, differentiation, and apoptosis. The induction of cyclooxygenase-2 (PTGS2/COX2) by this cytokine in the central nervous system (CNS) is found to contribute to inflammatory pain hypersensitivity. This gene and eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2.
Gene Symbol
  • IL1B
  • IL1F2
  • pro-interleukin-1-beta
  • IL1-BETA
  • Catabolin
  • IL-1
  • IL-1B
  • catabolin
Purification Method Protein G Purified
UniProt Number
UniProt Summary FUNCTION: SwissProt: P01584 # Produced by activated macrophages, IL-1 stimulates thymocyte proliferation by inducing IL-2 release, B-cell maturation and proliferation, and fibroblast growth factor activity. IL-1 proteins are involved in the inflammatory response, being identified as endogenous pyrogens, and are reported to stimulate the release of prostaglandin and collagenase from synovial cells.
SIZE: 269 amino acids; 30748 Da
SUBUNIT: Monomer.
SUBCELLULAR LOCATION: Secreted. Note=The lack of a specific hydrophobic segment in the precursor sequence suggests that IL-1 is released by damaged cells or is secreted by a mechanism differing from that used for other secretory proteins.
DOMAIN: SwissProt: P01584 The similarity among the IL-1 precursors suggests that the amino ends of these proteins serve some as yet undefined function.
SIMILARITY: Belongs to the IL-1 family.
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage Conditions Store at -20°C in undiluted aliquots for 1 year from date of shipment.
Packaging Information
Material Size 500 µg
Transport Information
Supplemental Information
Specifications

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